Uric Acid Stones Increase the Risk of Chronic Kidney Disease

Overview

Journal Urolithiasis

Publisher Springer

Specialty Urology

Date 2018 Mar 2

PMID 29492591

Citations 16

Authors

Ching-Chia Li

Tsu-Ming Chien

Wen-Jeng Wu

Chun-Nung Huang

Yii-Her Chou

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to compare the clinical characteristics of uric acid stones and their potential risk for chronic kidney disease (CKD). A total of 401 patients (196 with uric acid stone and 205 without) were enrolled from our database of patients with urolithiasis. We analyzed the clinical demographic features, stone location, urine chemistries, and renal function. There was a significant difference (p < 0.001) between the two groups in terms of age, with the higher mean age in the uric acid group. Patients with uric acid stones had much lower pH of urine (p < 0.001) and higher serum uric acid level (p = 0.002). Notably, those with uric acid stones had worse eGFR than those with non-uric acid stones. Multivariate analysis confirmed that age over 60 years (ORs = 9.19; 95% CI 3.5-24.3), female sex (ORs = 4.01; 95% CI 1.8-9.0), hyperuricemia (ORs = 8.47; 95% CI 1.6-43.5), and uric acid stone (OR = 2.86; 95% CI 1.2-6.7) were the independent predictors of poor prognoses in CKD. Therefore, an association exists between uric acid stones and higher prevalence of CKD. Patients with uric acid stones may need close monitoring of renal function during follow-up.

Citing Articles

Protein Intake and High Uric Acid Stone Risk.

Montgomery T, Nair H, Phadke M, Morhardt E, Ludvigson A, Motamedinia P Kidney Med. 2024; 6(9):100878.

PMID: 39279882 PMC: 11399574. DOI: 10.1016/j.xkme.2024.100878.

Urinary stone analysis and clinical characteristics of 496 patients in Taiwan.

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The awareness of renal stones amongst Syrian refugees in northern Jordan.

Alaqabani H, Omar H, Barham S, Al Zuaini H, Ugorenko A, Khaleel A PLoS One. 2024; 19(6):e0300999.

PMID: 38875284 PMC: 11178229. DOI: 10.1371/journal.pone.0300999.

Risk of incident chronic kidney disease among patients with urolithiasis: a nationwide longitudinal cohort study.

Kim J, Lee J, Park J, Chang T Clin Kidney J. 2024; 17(3):sfae030.

PMID: 38435351 PMC: 10906355. DOI: 10.1093/ckj/sfae030.

Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio.

Tung H, Liu C, Huang H, Lu Z, Liu C Sci Rep. 2023; 13(1):17686.

PMID: 37848540 PMC: 10582096. DOI: 10.1038/s41598-023-45034-1.

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