Inhibition of STAT1 Sensitizes Radioresistant Nasopharyngeal Carcinoma Cell Line CNE-2R to Radiotherapy

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 Mar 2

PMID 29492196

Citations 8

Authors

Song Qu

Ya Guo

Shi-Ting Huang

Xiao-Dong Zhu

Affiliations

Soon will be listed here.

Abstract

Radioresistance remains a major obstacle for clinicians in the treatment of nasopharyngeal carcinoma (NPC). Others and we have reported that signal transducer and activator of transcription 1 (STAT1) may be as an important gene for resistance to radiation. However, the relationship between STAT1 and radioresistance is still elusive. In this study, by constitutive silencing STAT1 in human radioresistant nasopharyngeal carcinoma CNE-2R cell line, we showed that inhibition of STAT1 enhanced radiosensitivity of CNE-2R. Furthermore, knockdown of STAT1 led to growth suppression and apoptosis promotion and . Moreover, cells with low STAT1 expression increased G2/M phase and decreased S phase at 2Gy. These result revealed that knockdown of stat1 expression could sensitizes the CNE-2R to radiotherapy, But the exact mechanism needs to be further clarified.

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