Clinical Evaluation of Haploidentical Hematopoietic Combined with Human Umbilical Cord-derived Mesenchymal Stem Cells in Severe Aplastic Anemia

Overview

Journal Eur J Med Res

Publisher Biomed Central

Specialty General Medicine

Date 2018 Mar 2

PMID 29490698

Citations 12

Authors

Lixin Xu

Zhouyang Liu

Yamei Wu

Xueliang Yang

Yongbin Cao

Xiaohong Li

Bei Yan

Songwei Li

Wanming Da

Xiaoxiong Wu

Affiliations

Soon will be listed here.

Abstract

Background: This study not only evaluated the clinical effects of treatment using haploidentical hematopoietic stem cells (haplo-HSCs) combined with human umbilical cord mesenchymal stem cells (UC-MSCs) in patients with severe aplastic anemia (SAA), but also investigated the factors related to graft versus host disease (GVHD).

Methods: Cotransplantation of haplo-HSCs and UC-MSCs was performed in 24 SAA patients. The conditioning regimens consisted of rabbit anti-human T-lymphocyte immunoglobulin (ATG), cyclophosphamide, and fludarabine with or without busulfan. GVHD was prevented using cyclosporine A, ATG, anti-CD25 monoclonal antibody, and mycophenolate material.

Results: The incidence of acute GVHD was 50%. The incidence of severe acute GVHD was not related to gender, age, donor-recipient relations, and patient/donor pair, while patient/donor pair (r = 0.541, P = 0.022) was significantly correlated with incidence of chronic GVHD. Upon follow-up for a median of 13 months, 5 of the 24 patients (20.8%) were dead. The survival rates at 3 and 6 months in all patients were 87.5% (21/24) and 83.3% (20/24), respectively.

Conclusion: Cotransplantation of haplo-HSCs combined with UC-MSCs was an effective and safe approach for the treatment of patients with SAA. The appropriate conditioning regimen and early treatment for infection also played a critical role in the success of HSCT.

Citing Articles

[Clinical analysis of 76 patients with severe aplastic anemia treated with haploid hematopoietic stem cell transplantation].

Zhang Y, Zhang G, Pang A, Yang D, Zhang R, Zhai W Zhonghua Xue Ye Xue Za Zhi. 2023; 44(3):202-210.

PMID: 37356981 PMC: 10119725. DOI: 10.3760/cma.j.issn.0253-2727.2023.03.005.

Mesenchymal Stem Cells in Acquired Aplastic Anemia: The Spectrum from Basic to Clinical Utility.

Wang X, Li J, Wu K, Yang S, Chao Y Int J Mol Sci. 2023; 24(5).

PMID: 36901900 PMC: 10003043. DOI: 10.3390/ijms24054464.

Combination of Haploidentical Hematopoietic Stem Cell Transplantation with Umbilical Cord-Derived Mesenchymal Stem Cells in Patients with Severe Aplastic Anemia: A Retrospective Controlled Study.

Sheng X, Li H, Hong L, Zhuang H Turk J Haematol. 2022; 39(2):117-129.

PMID: 35448935 PMC: 9160692. DOI: 10.4274/tjh.galenos.2022.2022.0084.

Human Umbilical Cord Mesenchymal Stem Cells: Current Literature and Role in Periodontal Regeneration.

Shaikh M, Shahzad Z, Tash E, Janjua O, Khan M, Zafar M Cells. 2022; 11(7).

PMID: 35406732 PMC: 8997495. DOI: 10.3390/cells11071168.

Comparable Outcomes and Health-Related Quality of Life for Severe Aplastic Anemia: Haploidentical Combined With a Single Cord Blood Unit Matched Related Transplants.

Lei M, Li X, Zhang Y, Qu Q, Jiao W, Zhou H Front Oncol. 2022; 11:714033.

PMID: 35117985 PMC: 8804318. DOI: 10.3389/fonc.2021.714033.

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