» Articles » PMID: 29490060

Actual Versus 'ideal' Antibiotic Prescribing for Common Conditions in English Primary Care

Overview
Date 2018 Mar 1
PMID 29490060
Citations 98
Authors
Affiliations
Soon will be listed here.
Abstract

Objectives: Previous work based on guidelines and expert opinion identified 'ideal' prescribing proportions-the overall proportion of consultations that should result in an antibiotic prescription-for common infectious conditions. Here, actual condition-specific prescribing proportions in primary care in England were compared with ideal prescribing proportions identified by experts.

Methods: All recorded consultations for common infectious conditions (cough, bronchitis, exacerbations of asthma or chronic obstructive pulmonary disease, sore throat, rhinosinusitis, otitis media, lower respiratory tract infection, upper respiratory tract infection, influenza-like illness, urinary tract infection, impetigo, acne, gastroenteritis) for 2013-15 were extracted from The Health Improvement Network (THIN) database. The proportions of consultations resulting in an antibiotic prescription were established, concentrating on acute presentations in patients without relevant comorbidities. These actual prescribing proportions were then compared with previously established 'ideal' proportions by condition.

Results: For most conditions, substantially higher proportions of consultations resulted in an antibiotic prescription than was deemed appropriate according to expert opinion. An antibiotic was prescribed in 41% of all acute cough consultations when experts advocated 10%. For other conditions the proportions were: bronchitis (actual 82% versus ideal 13%); sore throat (actual 59% versus ideal 13%); rhinosinusitis (actual 88% versus ideal 11%); and acute otitis media in 2- to 18-year-olds (actual 92% versus ideal 17%). Substantial variation between practices was found.

Conclusions: This work has identified substantial overprescribing of antibiotics in English primary care, and highlights conditions where this is most pronounced, particularly in respiratory tract conditions.

Citing Articles

Protocol for the development of an intervention to improve the use of Point-of-caRE DiagnostICs in the management of respiraTOry tRact infectionS in primary care (the PREDICTORS study).

OShea J, Hughes C, Molloy G, Cadogan C, Vellinga A, Fahey T HRB Open Res. 2025; 7:73.

PMID: 40060198 PMC: 11890267. DOI: 10.12688/hrbopenres.13962.2.


The Introduction of the Global Traditional, Complementary, and Integrative Healthcare (TCIH) Research Agenda on Antimicrobial Resistance and Its Added Value to the WHO and the WHO/FAO/UNEP/WOAH 2023 Research Agendas on Antimicrobial Resistance.

Baars E, Weiermayer P, Szoke H, van der Werf E Antibiotics (Basel). 2025; 14(1).

PMID: 39858387 PMC: 11762681. DOI: 10.3390/antibiotics14010102.


What are the general public's expectations about the likely duration of common acute infections? A cross-sectional survey of Australian residents.

Boaitey K, Bakhit M, Jones M, Hoffmann T BMJ Open. 2025; 14(12):e090190.

PMID: 39806681 PMC: 11667410. DOI: 10.1136/bmjopen-2024-090190.


Setting targets for antibiotic use in general practice in Europe: A scoping review.

Garzon-Orjuela N, Roche K, Vornhagen H, Moran A, Walkin S, Cullen W Eur J Gen Pract. 2024; 30(1):2430507.

PMID: 39607900 PMC: 11610282. DOI: 10.1080/13814788.2024.2430507.


C-reactive protein point-of-care testing in primary care-broader implementation needed to combat antimicrobial resistance.

Llor C, Plate A, Bjerrum L, Gentile I, Melbye H, Staiano A Front Public Health. 2024; 12:1397096.

PMID: 39100952 PMC: 11294078. DOI: 10.3389/fpubh.2024.1397096.


References
1.
Berni E, Butler C, Jenkins-Jones S, de Voogd H, Ouwens M, Morgan C . Comparative estimated effectiveness of antibiotic classes as initial and secondary treatments of respiratory tract infections: longitudinal analysis of routine data from UK primary care 1991-2012. Curr Med Res Opin. 2016; 32(6):1023-32. DOI: 10.1185/03007995.2016.1157459. View

2.
Little P, Stuart B, Moore M, Coenen S, Butler C, Godycki-Cwirko M . Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial. Lancet Infect Dis. 2012; 13(2):123-9. DOI: 10.1016/S1473-3099(12)70300-6. View

3.
Kenealy T, Arroll B . Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013; (6):CD000247. PMC: 7044720. DOI: 10.1002/14651858.CD000247.pub3. View

4.
Carter D, Charlett A, Conti S, Robotham J, Johnson A, Livermore D . A Risk Assessment of Antibiotic Pan-Drug-Resistance in the UK: Bayesian Analysis of an Expert Elicitation Study. Antibiotics (Basel). 2017; 6(1). PMC: 5372989. DOI: 10.3390/antibiotics6010009. View

5.
Lemiengre M, Van Driel M, Merenstein D, Young J, De Sutter A . Antibiotics for clinically diagnosed acute rhinosinusitis in adults. Cochrane Database Syst Rev. 2012; 10:CD006089. DOI: 10.1002/14651858.CD006089.pub4. View