Validation of Criteria for Major Depression Through Controlled Family Study

Overview

Journal J Affect Disord

Date 1986 Sep 1

PMID 2948985

Citations 8

Authors

E S Gershon

M M Weissman

J J Guroff

B A Prusoff

J F Leckman

Affiliations

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Abstract

As compared with depressed relatives of normals, depressed relatives of affective patients are more likely to have severe impairment or incapacitation in their major life role when depressed, and more likely to suffer multiple episodes. These findings suggest that among major depressions, these clinical criteria may usefully identify cases with a familial, possibly genetic, vulnerability.

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