Association Between Endogenous Cortisol Level and the Risk of Central Serous Chorioretinopathy: a Meta-analysis

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2018 Mar 1

PMID 29487822

Citations 4

Authors

Zhi-Qiao Liang

Lyu-Zhen Huang

Jin-Feng Qu

Ming-Wei Zhao

Affiliations

Soon will be listed here.

Abstract

Aim: To assess the association between endogenous cortisol level and the risk of central serous chorioretinopathy (CSC).

Methods: Case-control studies were systematically searched on PubMed, Embase, Cochrane, China National Knowledge Infrastructure (CNKI) for publishes between January 1990 and July 2017 to assess the association between endogenous cortisol level and CSC. The main endpoints were serum cortisol level at 8 a.m. and 24-hour urine 17-hydroxysteroids level. We assessed pooled data using a random-effects model.

Results: Of 86 identified studies, 5 were eligible included in our analysis. The 5 studies included a total of 315 participants, of whom 187 had CSC. Statistically significant association was observed between serum cortisol level (summary SMD=0.77, 95%CI=0.55-0.99), 24-hour urine 17-hydroxysteroids level (summary SMD=0.95, 95%CI=0.61-1.30), and the risk of CSC.

Conclusion: Endogenous cortisol level is associated with an increased risk of CSC. Combined treatment targeting the serum cortisol level at 8 a.m. and 24-hour urine 17-hydroxysteroids level can be a potential preventive strategy for individuals who are at risk of CSC and therapeutic strategy for patients with CSC.

Citing Articles

Time-dependent recurrence and resolution of pigment epithelial detachment in central serous chorioretinopathy.

Meng Y, Chen L, Li L, Xu Y, Su Y, Zhang L BMC Ophthalmol. 2023; 23(1):133.

PMID: 37013529 PMC: 10069014. DOI: 10.1186/s12886-023-02882-9.

Pathomechanisms in central serous chorioretinopathy: A recent update.

Zarnegar A, Ong J, Matsyaraja T, Arora S, Chhablani J Int J Retina Vitreous. 2023; 9(1):3.

PMID: 36670451 PMC: 9854068. DOI: 10.1186/s40942-023-00443-2.

Comment on: Effect of short-term meditation training in central serous chorioretinopathy.

Panigrahi P Indian J Ophthalmol. 2022; 70(5):1856.

PMID: 35502102 PMC: 9332941. DOI: 10.4103/ijo.IJO_3016_21.

Pathophysiology of central serous chorioretinopathy: a literature review with quality assessment.

Kanda P, Gupta A, Gottlieb C, Karanjia R, Coupland S, Bal M Eye (Lond). 2021; 36(5):941-962.

PMID: 34654892 PMC: 9046392. DOI: 10.1038/s41433-021-01808-3.

References

Norouzpour A, Abrishami M . Central serous chorioretinopathy: from glucocorticoids to light intensity. Int J Ophthalmol. 2016; 9(2):312-4. PMC: 4761749. DOI: 10.18240/ijo.2016.02.25. View

Bouzas E, Scott M, Mastorakos G, Chrousos G . Central serous chorioretinopathy in endogenous hypercortisolism. Arch Ophthalmol. 1993; 111(9):1229-33. DOI: 10.1001/archopht.1993.01090090081024. View

Nicholson B, Atchison E, Idris A, Bakri S . Central serous chorioretinopathy and glucocorticoids: an update on evidence for association. Surv Ophthalmol. 2017; 63(1):1-8. DOI: 10.1016/j.survophthal.2017.06.008. View

Zhao M, Valamanesh F, Celerier I, Savoldelli M, Jonet L, Jeanny J . The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Müller glial cells. FASEB J. 2010; 24(9):3405-15. DOI: 10.1096/fj.09-154344. View

KLIEN B . MACULAR DISEASES: CLINICAL MANIFESTATIONS. Trans Am Acad Ophthalmol Otolaryngol. 1965; 69:614-22. View

Worrall N, Misko T, Sullivan P, Hui J, Rodi C, Ferguson Jr T . Corticosteroids inhibit expression of inducible nitric oxide synthase during acute cardiac allograft rejection. Transplantation. 1996; 61(2):324-8. DOI: 10.1097/00007890-199601270-00028. View

Schubert C, Pryds A, Zeng S, Xie Y, Freund K, Spaide R . Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy. Hum Mutat. 2014; 35(7):859-67. PMC: 4215937. DOI: 10.1002/humu.22551. View

Baumal C, Martidis A, Truong S . Central serous chorioretinopathy associated with periocular corticosteroid injection treatment for HLA-B27-associated iritis. Arch Ophthalmol. 2004; 122(6):926-8. DOI: 10.1001/archopht.122.6.926. View

Zakir S, Shukla M, Simi Z, Ahmad J, Sajid M . Serum cortisol and testosterone levels in idiopathic central serous chorioretinopathy. Indian J Ophthalmol. 2009; 57(6):419-22. PMC: 2812758. DOI: 10.4103/0301-4738.57143. View

10.

Errera M, Kohly R, da Cruz L . Pregnancy-associated retinal diseases and their management. Surv Ophthalmol. 2013; 58(2):127-42. DOI: 10.1016/j.survophthal.2012.08.001. View

11.

Miller W, Auchus R . The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev. 2010; 32(1):81-151. PMC: 3365799. DOI: 10.1210/er.2010-0013. View

12.

Iida T, Spaide R, Negrao S, Carvalho C, Yannuzzi L . Central serous chorioretinopathy after epidural corticosteroid injection. Am J Ophthalmol. 2001; 132(3):423-5. DOI: 10.1016/s0002-9394(01)00970-9. View

13.

Ramamoorthy S, Cidlowski J . Corticosteroids: Mechanisms of Action in Health and Disease. Rheum Dis Clin North Am. 2015; 42(1):15-31, vii. PMC: 4662771. DOI: 10.1016/j.rdc.2015.08.002. View

14.

Yannuzzi L . Type A behavior and central serous chorioretinopathy. Trans Am Ophthalmol Soc. 1986; 84:799-845. PMC: 1298752. View

15.

Chan L, Adam R, Adam D . Localized topical steroid use and central serous retinopathy. J Dermatolog Treat. 2016; 27(5):425-6. DOI: 10.3109/09546634.2015.1136049. View

16.

Tufan H, Gencer B, Taskiran Comez A . Serum cortisol and testosterone levels in chronic central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol. 2012; 251(3):677-80. DOI: 10.1007/s00417-012-2075-8. View

17.

Garg S, Dada T, Talwar D, Biswas N . Endogenous cortisol profile in patients with central serous chorioretinopathy. Br J Ophthalmol. 1998; 81(11):962-4. PMC: 1722041. DOI: 10.1136/bjo.81.11.962. View

18.

Crippa A, Khudyakov P, Wang M, Orsini N, Spiegelman D . A new measure of between-studies heterogeneity in meta-analysis. Stat Med. 2016; 35(21):3661-75. DOI: 10.1002/sim.6980. View

19.

Han J, Hwang J, Kim J, Park K, Woo S . Changes in choroidal thickness after systemic administration of high-dose corticosteroids: a pilot study. Invest Ophthalmol Vis Sci. 2013; 55(1):440-5. DOI: 10.1167/iovs.13-12854. View

20.

Eom Y, Oh J, Kim S, Huh K . Systemic factors associated with central serous chorioretinopathy in Koreans. Korean J Ophthalmol. 2012; 26(4):260-4. PMC: 3408530. DOI: 10.3341/kjo.2012.26.4.260. View