Liver Cirrhosis-effect on QT Interval and Cardiac Autonomic Nervous System Activity

Overview

Journal World J Gastrointest Pathophysiol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2018 Mar 1

PMID 29487764

Citations 18

Authors

Elias Tsiompanidis

Spyros I Siakavellas

Anastasios Tentolouris

Ioanna Eleftheriadou

Stamatia Chorepsima

Anastasios Manolakis

Konstantinos Oikonomou

Nikolaos Tentolouris

Affiliations

Soon will be listed here.

Abstract

Aim: To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy (CAN).

Methods: A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval (QTc) and their dispersions (dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of CAN was based upon the battery of the tests proposed by Ewing and Clarke and the consensus statements of the American Diabetes Association. CAN was diagnosed when two out of the four classical Ewing tests were abnormal.

Results: QT, QTc and their dispersions were significantly longer ( < 0.01) in patients with cirrhosis than in controls. No significant differences in QT interval were found among the subgroups according to the etiology of cirrhosis. Multivariate regression analysis after controlling for age, gender and duration of cirrhosis demonstrated significant association between QT and presence of diabetes mellitus [standardized regression coefficient (beta) = 0.45, = 0.02] and treatment with diuretics (beta = 0.55, = 0.03), but not with the Child-Pugh score ( = 0.54). Prevalence of CAN was common (54.9%) among patients with cirrhosis and its severity was associated with the Child-Pugh score ( = 0.33, = 0.02). Moreover, patients with decompensated cirrhosis had more severe CAN that those with compensated cirrhosis ( = 0.03). No significant association was found between severity of CAN and QT interval duration.

Conclusion: Patients with cirrhosis have QT prolongation. Treatment with diuretics is associated with longer QT. CAN is common in patients with cirrhosis and its severity is associated with severity of the disease.

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