Infant FMRI: A Model System for Cognitive Neuroscience
Overview
Affiliations
Our understanding of the typical human brain has benefitted greatly from studying different kinds of brains and their associated behavioral repertoires, including animal models and neuropsychological patients. This same comparative perspective can be applied to early development - the environment, behavior, and brains of infants provide a model system for understanding how the mature brain works. This approach requires noninvasive methods for measuring brain function in awake, behaving infants. fMRI is becoming increasingly viable for this purpose, with the unique ability to precisely measure the entire brain, including both cortical and subcortical structures. Here we discuss potential lessons from infant fMRI for several domains of adult cognition and consider the challenges of conducting such research and how they might be mitigated.
Movies reveal the fine-grained organization of infant visual cortex.
Ellis C, Yates T, Arcaro M, Turk-Browne N Elife. 2025; 12.
PMID: 40047799 PMC: 11884787. DOI: 10.7554/eLife.92119.
Carreno C, Evans M, Lockhart B, Chinaka O, Katz B, Bell M Dev Cogn Neurosci. 2024; 71():101481.
PMID: 39647348 PMC: 11667636. DOI: 10.1016/j.dcn.2024.101481.
Wang J, Li H, Cecil K, Altaye M, Parikh N, He L Comput Methods Programs Biomed. 2024; 257:108479.
PMID: 39489076 PMC: 11563839. DOI: 10.1016/j.cmpb.2024.108479.
Liu J, Chen H, Cornea E, Gilmore J, Gao W Cereb Cortex. 2023; 33(19):10367-10379.
PMID: 37585708 PMC: 10545442. DOI: 10.1093/cercor/bhad288.
Nielsen A, Graham A, Sylvester C Biol Psychiatry. 2023; 93(10):880-892.
PMID: 36935330 PMC: 10149573. DOI: 10.1016/j.biopsych.2023.01.010.