Prenatal Exposure to TCDD and Atopic Conditions in the Seveso Second Generation: a Prospective Cohort Study

Overview

Journal Environ Health

Publisher Biomed Central

Specialty Environmental Health

Date 2018 Feb 28

PMID 29482571

Citations 7

Authors

Morgan Ye

Marcella Warner

Paolo Mocarelli

Paolo Brambilla

Brenda Eskenazi

Affiliations

Soon will be listed here.

Abstract

Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental contaminant that can bioaccumulate in humans, cross the placenta, and cause immunological effects in children, including altering their risk of developing allergies. On July 10, 1976, a chemical explosion in Seveso, Italy, exposed nearby residents to a high amount of TCDD. In 1996, the Seveso Women's Health Study (SWHS) was established to study the effects of TCDD on women's health. Using data from the Seveso Second Generation Health Study, we aim to examine the effect of prenatal exposure to TCDD on the risk of atopic conditions in SWHS children born after the explosion.

Methods: Individual-level TCDD was measured in maternal serum collected soon after the accident. In 2014, we initiated the Seveso Second Generation Health Study to follow-up the children of the SWHS cohort who were born after the explosion or who were exposed in utero to TCDD. We enrolled 677 children, and cases of atopic conditions, including eczema, asthma, and hay fever, were identified by self-report during personal interviews with the mothers and children. Log-binomial and Poisson regressions were used to determine the association between prenatal TCDD and atopic conditions.

Results: A 10-fold increase in 1976 maternal serum TCDD (logTCDD) was not significantly associated with asthma (adjusted relative risk (RR) = 0.93; 95% CI: 0.61, 1.40) or hay fever (adjusted RR = 0.99; 95% CI: 0.76, 1.27), but was significantly inversely associated with eczema (adjusted RR = 0.63; 95% CI: 0.40, 0.99). Maternal TCDD estimated at pregnancy was not significantly associated with eczema, asthma, or hay fever. There was no strong evidence of effect modification by child sex.

Conclusions: Our results suggest that maternal serum TCDD near the time of explosion is associated with lower risk of eczema, which supports other evidence pointing to the dysregulated immune effects of TCDD.

Citing Articles

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the immune system maternal-fetal interface during palatal development.

Yongkai W, Shuhui Z, Li M J Mol Histol. 2024; 56(1):60.

PMID: 39730832 PMC: 11680613. DOI: 10.1007/s10735-024-10331-0.

Addressing the water-energy nexus: A focus on the barriers and potentials of harnessing wastewater treatment processes for biogas production in Sub Saharan Africa.

Ijoma G, Mutungwazi A, Mannie T, Nurmahomed W, Matambo T, Hildebrandt D Heliyon. 2022; 8(5):e09385.

PMID: 35600457 PMC: 9118499. DOI: 10.1016/j.heliyon.2022.e09385.

Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response.

Vogeley C, Sondermann N, Woeste S, Momin A, Gilardino V, Hartung F Environ Int. 2022; 158:106989.

PMID: 34991250 PMC: 8852774. DOI: 10.1016/j.envint.2021.106989.

A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood.

Turco A, Oakes S, Keil Stietz K, Dunham C, Joseph D, Chathurvedula T Dis Model Mech. 2021; 14(7).

PMID: 34318329 PMC: 8326766. DOI: 10.1242/dmm.049068.

Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho.

Furue M, Ishii Y, Tsukimori K, Tsuji G Int J Mol Sci. 2021; 22(2).

PMID: 33445793 PMC: 7828254. DOI: 10.3390/ijms22020708.

References

Di Domenico A, Silano V, Viviano G, Zapponi G . Accidental release of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at Sèveso, Italy. II. TCDD distribution in the soil surface layer. Ecotoxicol Environ Saf. 1980; 4(3):298-320. DOI: 10.1016/0147-6513(80)90032-9. View

Miyashita C, Sasaki S, Saijo Y, Washino N, Okada E, Kobayashi S . Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy. Environ Res. 2011; 111(4):551-8. DOI: 10.1016/j.envres.2011.01.021. View

Zou G, Donner A . Extension of the modified Poisson regression model to prospective studies with correlated binary data. Stat Methods Med Res. 2011; 22(6):661-70. DOI: 10.1177/0962280211427759. View

Baccarelli A, Pesatori A, Masten S, Patterson Jr D, Needham L, Mocarelli P . Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy. Toxicol Lett. 2004; 149(1-3):287-93. DOI: 10.1016/j.toxlet.2003.12.062. View

Laiosa M, Tate E, Ahrenhoerster L, Chen Y, Wang D . Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-term Self-renewal of Murine Hematopoietic Stem Cells. Environ Health Perspect. 2015; 124(7):957-65. PMC: 4937855. DOI: 10.1289/ehp.1509820. View

Ellwood P, Asher M, Beasley R, Clayton T, Stewart A . The international study of asthma and allergies in childhood (ISAAC): phase three rationale and methods. Int J Tuberc Lung Dis. 2005; 9(1):10-6. View

Kim H, Kim E, Park Y, Yu J, Hong S, Jeon S . Immunotoxicological effects of Agent Orange exposure to the Vietnam War Korean veterans. Ind Health. 2003; 41(3):158-66. DOI: 10.2486/indhealth.41.158. View

Akins J, Waldrep K, Bernert Jr J . The estimation of total serum lipids by a completely enzymatic 'summation' method. Clin Chim Acta. 1989; 184(3):219-26. DOI: 10.1016/0009-8981(89)90054-5. View

Sly P, Holt P . Role of innate immunity in the development of allergy and asthma. Curr Opin Allergy Clin Immunol. 2011; 11(2):127-31. DOI: 10.1097/ACI.0b013e32834487c6. View

10.

Husband A, Gleeson M . Ontogeny of mucosal immunity--environmental and behavioral influences. Brain Behav Immun. 1996; 10(3):188-204. DOI: 10.1006/brbi.1996.0018. View

11.

Patterson Jr D, Hampton L, Lapeza Jr C, Belser W, Green V, Alexander L . High-resolution gas chromatographic/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Anal Chem. 1987; 59(15):2000-5. DOI: 10.1021/ac00142a023. View

12.

Stolevik S, Nygaard U, Namork E, Haugen M, Kvalem H, Meltzer H . Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. Food Chem Toxicol. 2011; 49(8):1843-8. DOI: 10.1016/j.fct.2011.05.002. View

13.

Mustafa A, Holladay S, Witonsky S, Sponenberg D, Karpuzoglu E, Gogal Jr R . A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice. Toxicology. 2011; 290(2-3):156-68. PMC: 3226876. DOI: 10.1016/j.tox.2011.08.021. View

14.

Ten Tusscher G, Steerenberg P, Van Loveren H, Vos J, von dem Borne A, Westra M . Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure. Environ Health Perspect. 2003; 111(12):1519-23. PMC: 1241656. DOI: 10.1289/ehp.5715. View

15.

Ernst M, Flesch-Janys D, Morgenstern I, Manz A . Immune cell functions in industrial workers after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: dissociation of antigen-specific T-cell responses in cultures of diluted whole blood and of isolated peripheral blood mononuclear cells. Environ Health Perspect. 1998; 106 Suppl 2:701-5. PMC: 1533402. DOI: 10.1289/ehp.98106701. View

16.

Nakamoto M, Arisawa K, Uemura H, Katsuura S, Takami H, Sawachika F . Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population. Int Arch Occup Environ Health. 2012; 86(8):849-59. DOI: 10.1007/s00420-012-0819-8. View

17.

Loertscher J, Sattler C . 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture. Toxicol Appl Pharmacol. 2001; 175(2):121-9. DOI: 10.1006/taap.2001.9202. View

18.

Ahrenhoerster L, Tate E, Lakatos P, Wang X, Laiosa M . Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates capacity of hematopoietic stem cells to undergo lymphocyte differentiation. Toxicol Appl Pharmacol. 2014; 277(2):172-82. PMC: 4083512. DOI: 10.1016/j.taap.2014.03.020. View

19.

Sutter C, Bodreddigari S, Campion C, Wible R, Sutter T . 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation. Toxicol Sci. 2011; 124(1):128-37. PMC: 3196651. DOI: 10.1093/toxsci/kfr205. View

20.

Jusko T, De Roos A, Schwartz S, Lawrence B, Palkovicova L, Nemessanyi T . Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants. J Immunotoxicol. 2011; 8(1):95-100. PMC: 3086069. DOI: 10.3109/1547691X.2010.549096. View