Renalase Contributes to Protection Against Renal Fibrosis Via Inhibiting Oxidative Stress in Rats

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2018 Feb 25

PMID 29476431

Citations 19

Authors

Yiru Wu

Liyan Wang

Xiaoqi Wang

Yahui Wang

Qidong Zhang

Wenhu Liu

Affiliations

Soon will be listed here.

Abstract

Background: Renal interstitial fibrosis (RIF) is a common pathway for progression of chronic kidney disease (CKD) to end-stage renal disease. In our previous study, it has been provided that renalase can ameliorate renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats. The other mechanism of renalase to alleviate renal fibrosis should be explored.

Materials And Methods: In this study, we evaluated the role of oxidative stress in UUO rats and epithelial-mesenchymal transition (EMT) in human proximal renal tubular epithelial (HK-2) cells and examined the association of renalase.

Results: Oxidative stress could induce EMT and fibrosis in HK-2 cells. In the UUO model, oxidative stress occurred and maintained at a high level leading to RIF. Administration of renalase by adenovirus significantly attenuated oxidative stress and further in vitro study showed that renalase can exert anti-fibrosis by inhibiting oxidative stress.

Conclusion: Our results prompt another mechanism of anti-fibrotic renal protection of renalase, which may be partly associated with inhibiting oxidative stress. These data provided another theoretical basis that supplementation with exogenous renalase may be a promising strategy for slowing or halting the progression of CKD.

Citing Articles

Renalase protects against podocyte injury by inhibiting oxidative stress and apoptosis in diabetic nephropathy.

Wu Y, Feng Y, Yu Y, Bai Y, Diao Z, Liu W Open Life Sci. 2024; 19(1):20220940.

PMID: 39588120 PMC: 11588010. DOI: 10.1515/biol-2022-0940.

Renalase Potential as a Marker and Therapeutic Target in Chronic Kidney Disease.

Serban-Feier L, Cuiban E, Gogosoiu E, Stepan E, Radulescu D Biomedicines. 2024; 12(8).

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Renalase alleviates salt-induced kidney necroptosis and inflammation.

Wang Y, Jia H, Gao K, Du M, Chu C, Wang D Hypertens Res. 2024; 47(10):2811-2825.

PMID: 39117946 DOI: 10.1038/s41440-024-01814-4.

The role of PI3K/Akt signaling pathway in chronic kidney disease.

Wang H, Gao L, Zhao C, Fang F, Liu J, Wang Z Int Urol Nephrol. 2024; 56(8):2623-2633.

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The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease.

Stojanovic D, Stojanovic M, Milenkovic J, Velickov A, Ignjatovic A, Milojkovic M Cells. 2023; 12(12).

PMID: 37371077 PMC: 10297141. DOI: 10.3390/cells12121607.

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