Circular RNA GRB10 As a Competitive Endogenous RNA Regulating Nucleus Pulposus Cells Death in Degenerative Intervertebral Disk

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2018 Feb 25

PMID 29476072

Citations 40

Authors

Wei Guo

Bin Zhang

Kun Mu

Shi-Qing Feng

Zhan-Yin Dong

Guang-Zhi Ning

Hao-Ran Li

Shen Liu

Ling Zhao

Yan Li

Bing-Bing Yu

Hui-Quan Duan

Chao Sun

Yong-Jin Li

Affiliations

Soon will be listed here.

Abstract

Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.

Citing Articles

Circular RNA and intervertebral disc degeneration: unravelling mechanisms and implications.

Xie G, Wu T, Ji G, Wu H, Lai Y, Wei B Front Mol Biosci. 2024; 10:1302017.

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Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis.

Li W, Li X, Gao Y, Xiong C, Tang Z Orthop Surg. 2023; 15(12):3015-3025.

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The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration.

Li Y, Zhou S, Hu X, Lu S Noncoding RNA Res. 2023; 8(4):633-640.

PMID: 37780894 PMC: 10539873. DOI: 10.1016/j.ncrna.2023.09.004.

ERBB2-PTGS2 axis promotes intervertebral disc degeneration by regulating senescence of nucleus pulposus cells.

Li Z, An F BMC Musculoskelet Disord. 2023; 24(1):504.

PMID: 37340393 PMC: 10280935. DOI: 10.1186/s12891-023-06625-1.

tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells.

Pan J, Liu Z, Shen B, Xu J, Dai G, Xu W J Orthop Surg Res. 2023; 18(1):413.

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