Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2018 Feb 24

PMID 29473753

Citations 121

Authors

Yu Zhang

Kaimin Cai

Chao Li

Qin Guo

Qinjun Chen

Xi He

Lisha Liu

Yujie Zhang

Yifei Lu

Xinli Chen

Tao Sun

Yongzhuo Huang

Jianjun Cheng

Chen Jiang

Affiliations

Soon will be listed here.

Abstract

Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce their reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed to further improve the in situ penetration efficiency of chemo-drug-loaded membrane delivery-system formulations and their release profiles at the tumor site. Here, a macrophage-membrane-coated nanoparticle is developed for tumor-targeted chemotherapy delivery with a controlled release profile in response to tumor microenvironment stimuli. Upon fulfilling its mission of tumor homing and RES evasion, the macrophage-membrane coating can be shed via morphological changes driven by extracellular microenvironment stimuli. The nanoparticles discharged from the outer membrane coating show penetration efficiency enhanced by their size advantage and surface modifications. After internalization by the tumor cells, the loaded drug is quickly released from the nanoparticles in response to the endosome pH. The designed macrophage-membrane-coated nanoparticle (cskc-PPiP/PTX@Ma) exhibits an enhanced therapeutic effect inherited from both membrane-derived tumor homing and step-by-step controlled drug release. Thus, the combination of a biomimetic cell membrane and a cascade-responsive polymeric nanoparticle embodies an effective drug delivery system tailored to the tumor microenvironment.

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References

Tian X, Aruva M, Qin W, Zhu W, Duffy K, Sauter E . External imaging of CCND1 cancer gene activity in experimental human breast cancer xenografts with 99mTc-peptide-peptide nucleic acid-peptide chimeras. J Nucl Med. 2004; 45(12):2070-82. View

Gao W, Hu C, Fang R, Luk B, Su J, Zhang L . Surface functionalization of gold nanoparticles with red blood cell membranes. Adv Mater. 2013; 25(26):3549-53. PMC: 4138311. DOI: 10.1002/adma.201300638. View

Hyvonen Z, Hamalainen V, Ruponen M, Lucas B, Rejman J, Vercauteren D . Elucidating the pre- and post-nuclear intracellular processing of 1,4-dihydropyridine based gene delivery carriers. J Control Release. 2012; 162(1):167-75. DOI: 10.1016/j.jconrel.2012.06.013. View

Anderson D, Akinc A, Hossain N, Langer R . Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Mol Ther. 2005; 11(3):426-34. DOI: 10.1016/j.ymthe.2004.11.015. View

Tian X, Chakrabarti A, Amirkhanov N, Aruva M, Zhang K, Mathew B . External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras. Ann N Y Acad Sci. 2005; 1059:106-44. DOI: 10.1196/annals.1339.038. View

Peppicelli S, Bianchini F, Calorini L . Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy. Cancer Metastasis Rev. 2014; 33(2-3):823-32. DOI: 10.1007/s10555-014-9506-4. View

Sun B, Kobayashi H, Le N, Yoo T, Drumm D, Paik C . Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism. Cancer Res. 1997; 57(13):2754-9. View

Rehman Z, Hoekstra D, Zuhorn I . Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. ACS Nano. 2013; 7(5):3767-77. DOI: 10.1021/nn3049494. View

Luk B, Zhang L . Cell membrane-camouflaged nanoparticles for drug delivery. J Control Release. 2015; 220(Pt B):600-7. PMC: 4688192. DOI: 10.1016/j.jconrel.2015.07.019. View

10.

Magana I, Yendluri R, Adhikari P, Goodrich G, Schwartz J, Sherer E . Suppression of the reticuloendothelial system using λ-carrageenan to prolong the circulation of gold nanoparticles. Ther Deliv. 2015; 6(7):777-83. DOI: 10.4155/tde.15.33. View

11.

Zheng N, Song Z, Liu Y, Zhang R, Zhang R, Yao C . Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery. J Control Release. 2015; 205:231-9. DOI: 10.1016/j.jconrel.2015.02.014. View

12.

Hagemann T, Balkwill F, Lawrence T . Inflammation and cancer: a double-edged sword. Cancer Cell. 2007; 12(4):300-1. PMC: 2592547. DOI: 10.1016/j.ccr.2007.10.005. View

13.

Yoneda T, Hiasa M, Nagata Y, Okui T, White F . Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain. Biochim Biophys Acta. 2015; 1848(10 Pt B):2677-84. PMC: 5356024. DOI: 10.1016/j.bbamem.2015.02.004. View

14.

Ryan S, Brayden D . Progress in the delivery of nanoparticle constructs: towards clinical translation. Curr Opin Pharmacol. 2014; 18:120-8. DOI: 10.1016/j.coph.2014.09.019. View

15.

Litzenburger B, Creighton C, Tsimelzon A, Chan B, Hilsenbeck S, Wang T . High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy. Clin Cancer Res. 2010; 17(8):2314-27. PMC: 3073089. DOI: 10.1158/1078-0432.CCR-10-1903. View

16.

Long K, Beatty G . Harnessing the antitumor potential of macrophages for cancer immunotherapy. Oncoimmunology. 2014; 2(12):e26860. PMC: 3902119. DOI: 10.4161/onci.26860. View

17.

Liu T, Choi H, Zhou R, Chen I . Quantitative evaluation of the reticuloendothelial system function with dynamic MRI. PLoS One. 2014; 9(8):e103576. PMC: 4121285. DOI: 10.1371/journal.pone.0103576. View

18.

Liebmann J, Cook J, Mitchell J . Cremophor EL, solvent for paclitaxel, and toxicity. Lancet. 1993; 342(8884):1428. DOI: 10.1016/0140-6736(93)92789-v. View

19.

Jiang S, Cao Z . Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications. Adv Mater. 2010; 22(9):920-32. DOI: 10.1002/adma.200901407. View

20.

Cai K, Wang A, Yin L, Cheng J . Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties. J Control Release. 2017; 263:211-222. DOI: 10.1016/j.jconrel.2016.11.034. View