Body Mass Index is Independently Associated with Xanthine Oxidase Activity in Overweight/obese Population

Overview

Journal Eat Weight Disord

Publisher Springer

Date 2018 Feb 23

PMID 29470797

Citations 15

Authors

Aleksandra Klisic

Gordana Kocic

Nebojsa Kavaric

Milovan Jovanovic

Verica Stanisic

Ana Ninic

Affiliations

Soon will be listed here.

Abstract

Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity.

Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained.

Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = - 0.489, p < 0.001) are the independent predictors of XO activity (R-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction.

Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population.

Level Of Evidence: Level V: cross-sectional descriptive study.

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References

Laaksonen D, Niskanen L, Nyyssonen K, Punnonen K, Tuomainen T, Valkonen V . C-reactive protein and the development of the metabolic syndrome and diabetes in middle-aged men. Diabetologia. 2004; 47(8):1403-10. DOI: 10.1007/s00125-004-1472-x. View

Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K . Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis. Mediators Inflamm. 2017; 2016:8603164. PMC: 5192336. DOI: 10.1155/2016/8603164. View

Savini I, Catani M, Evangelista D, Gasperi V, Avigliano L . Obesity-associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci. 2013; 14(5):10497-538. PMC: 3676851. DOI: 10.3390/ijms140510497. View

Hallenborg P, Petersen R, Kouskoumvekaki I, Newman J, Madsen L, Kristiansen K . The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects. Prog Lipid Res. 2015; 61:149-62. DOI: 10.1016/j.plipres.2015.11.002. View

Klisic A, Vasiljevic N, Simic T, Djukic T, Maksimovic M, Matic M . Association between C-reactive protein, anthropometric and lipid parameters among healthy normal weight and overweight postmenopausal women in Montenegro. Lab Med. 2014; 45(1):12-6. DOI: 10.1309/lmi6i2rn7ampeuul. View

Tam H, Kelly A, Fox C, Nathan B, Johnson L . Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity. Child Obes. 2016; 12(4):286-91. PMC: 5911696. DOI: 10.1089/chi.2015.0051. View

Klisic A, Kotur-Stevuljevic J, Kavaric N, Martinovic M, Matic M . The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. Eat Weight Disord. 2016; 23(1):133-141. DOI: 10.1007/s40519-016-0325-1. View

Richette P, Poitou C, Manivet P, Denis J, Bouillot J, Clement K . Weight Loss, Xanthine Oxidase, and Serum Urate Levels: A Prospective Longitudinal Study of Obese Patients. Arthritis Care Res (Hoboken). 2016; 68(7):1036-42. DOI: 10.1002/acr.22798. View

Petelin A, Tedeschi P, Maietti A, Jurdana M, Brandolini V, Jenko Praznikar Z . Total Serum Antioxidant Capacity in Healthy Normal Weight and Asymptomatic Overweight Adults. Exp Clin Endocrinol Diabetes. 2017; 125(7):470-477. DOI: 10.1055/s-0043-107783. View

10.

Papaetis G, Papakyriakou P, Panagiotou T . Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Arch Med Sci. 2015; 11(3):463-82. PMC: 4495144. DOI: 10.5114/aoms.2015.52350. View

11.

Boban M, Kocic G, Radenkovic S, Pavlovic R, Cvetkovic T, Deljanin-Ilic M . Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease. Ren Fail. 2014; 36(4):613-8. DOI: 10.3109/0886022X.2014.882240. View

12.

Miric D, Kisic B, Filipovic-Danic S, Grbic R, Dragojevic I, Miric M . Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy. J Diabetes Res. 2016; 2016:4370490. PMC: 5124663. DOI: 10.1155/2016/4370490. View

13.

Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H . Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. Arterioscler Thromb Vasc Biol. 2011; 32(2):291-8. DOI: 10.1161/ATVBAHA.111.234559. View

14.

Aranda R, Domenech E, Rus A, Real J, Sastre J, Vina J . Age-related increase in xanthine oxidase activity in human plasma and rat tissues. Free Radic Res. 2007; 41(11):1195-200. DOI: 10.1080/10715760701481461. View

15.

Real J, Martinez-Hervas S, Garcia-Garcia A, Civera M, Pallardo F, Ascaso J . Circulating mononuclear cells nuclear factor-kappa B activity, plasma xanthine oxidase, and low grade inflammatory markers in adult patients with familial hypercholesterolaemia. Eur J Clin Invest. 2009; 40(2):89-94. DOI: 10.1111/j.1365-2362.2009.02218.x. View

16.

Chedraui P, Escobar G, Ramirez C, Perez-Lopez F, Hidalgo L, Mannella P . Nitric oxide and pro-inflammatory cytokine serum levels in postmenopausal women with the metabolic syndrome. Gynecol Endocrinol. 2012; 28(10):787-91. DOI: 10.3109/09513590.2012.671395. View

17.

Miyata S, Noda A, Hara Y, Ueyama J, Kitaichi K, Kondo T . Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers. Exp Clin Endocrinol Diabetes. 2017; 125(10):684-689. DOI: 10.1055/s-0043-110054. View

18.

Chiney M, Schwarzenberg S, Johnson L . Altered xanthine oxidase and N-acetyltransferase activity in obese children. Br J Clin Pharmacol. 2011; 72(1):109-15. PMC: 3141192. DOI: 10.1111/j.1365-2125.2011.03959.x. View

19.

El-Bassossy H, Watson M . Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system. J Transl Med. 2015; 13:82. PMC: 4355989. DOI: 10.1186/s12967-015-0445-9. View

20.

Tam H, Kelly A, Metzig A, Steinberger J, Johnson L . Xanthine oxidase and cardiovascular risk in obese children. Child Obes. 2014; 10(2):175-80. PMC: 3992000. DOI: 10.1089/chi.2013.0098. View