Associations Between Ambient Particulate Matter and Nitrogen Dioxide and Chronic Obstructive Pulmonary Diseases in Adults and Effect Modification by Demographic and Lifestyle Factors

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2018 Feb 22

PMID 29463050

Citations 18

Authors

Dirga Kumar Lamichhane

Jong Han Leem

Hwan Cheol Kim

Affiliations

Soon will be listed here.

Abstract

This study was undertaken to investigate the associations between chronic exposure to particulate matter of medium aerodynamic diameter ≤10 or ≤2.5 µm (PM or PM) and nitrogen dioxide (NO₂) levels and lung function and to examine a possible change in these relationships by demographic and lifestyle factors. Chronic obstructive pulmonary disease (COPD) was defined using the Global Initiative for COPD criteria (forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) of <70%). Associations of lung function and COPD with PM or PM or NO₂ were examined using linear and logistic regression analyses among 1264 Korean adults. The highest tertiles of PM (≥37.1 μg/m³) and NO₂ (≥53.8 μg/m³) exposure were significantly associated with COPD (highest versus lowest tertile of PM: adjusted odds ratio (OR) = 1.79, 95% CI: 1.02-3.13; highest versus lowest tertile of NO₂: adjusted OR = 1.83, 95% CI: 1.04-3.21). A 10 μg/m³ increase in PM concentration was associated with a 1.85 L (95% CI -3.65 to -0.05) decrease in FEV1 and a 1.73 L (95% CI -3.35 to -0.12) decrease in FVC, with the strongest negative association among older people and those with less education. Reduced lung function was associated with PM exposure in subjects with no physical activity. This study provides evidence that exposure to ambient air pollution has adverse effects on lung function in adults.

Citing Articles

Impacts from air pollution on respiratory disease outcomes: a meta-analysis.

Su J, Aslebagh S, Shahriary E, Barrett M, Balmes J Front Public Health. 2024; 12:1417450.

PMID: 39444957 PMC: 11497638. DOI: 10.3389/fpubh.2024.1417450.

Diagnostic Challenges and Pathogenetic Differences in Biomass-Smoke-Induced versus Tobacco-Smoke-Induced COPD: A Comparative Review.

Dutta J, Singh S, Greeshma M, Mahesh P, Mabalirajan U Diagnostics (Basel). 2024; 14(19).

PMID: 39410558 PMC: 11475549. DOI: 10.3390/diagnostics14192154.

Effects of traffic-related air and noise pollution exposure on allergic diseases in the elderly: an observational study.

Tagliaferro S, Pirona F, Fasola S, Stanisci I, Sarno G, Baldacci S Ann Med. 2024; 56(1):2398193.

PMID: 39283054 PMC: 11407406. DOI: 10.1080/07853890.2024.2398193.

Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD.

Chung C, Park S, Huh J, Kim N, Shon C, Oh E J Inflamm (Lond). 2024; 21(1):13.

PMID: 38654364 PMC: 11041029. DOI: 10.1186/s12950-024-00384-z.

Fire-Pollutant-Atmosphere Components and Its Impact on Mortality in Portugal During Wildfire Seasons.

Duarte E, Salgueiro V, Costa M, Lucio P, Potes M, Bortoli D Geohealth. 2023; 7(10):e2023GH000802.

PMID: 37811341 PMC: 10558046. DOI: 10.1029/2023GH000802.

References

Adam M, Schikowski T, Carsin A, Cai Y, Jacquemin B, Sanchez M . Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis. Eur Respir J. 2014; 45(1):38-50. PMC: 4318659. DOI: 10.1183/09031936.00130014. View

Mannino D, Buist A, Vollmer W . Chronic obstructive pulmonary disease in the older adult: what defines abnormal lung function?. Thorax. 2006; 62(3):237-41. PMC: 2117148. DOI: 10.1136/thx.2006.068379. View

Hatzis C, Godleski J, Gonzalez-Flecha B, Wolfson J, Koutrakis P . Ambient particulate matter exhibits direct inhibitory effects on oxidative stress enzymes. Environ Sci Technol. 2006; 40(8):2805-11. DOI: 10.1021/es0518732. View

Santos U, Garcia M, Braga A, Pereira L, An Lin C, Afonso de Andre P . Association between Traffic Air Pollution and Reduced Forced Vital Capacity: A Study Using Personal Monitors for Outdoor Workers. PLoS One. 2016; 11(10):e0163225. PMC: 5053536. DOI: 10.1371/journal.pone.0163225. View

Ko F, Hui D . Air pollution and chronic obstructive pulmonary disease. Respirology. 2011; 17(3):395-401. DOI: 10.1111/j.1440-1843.2011.02112.x. View

Ciencewicki J, Trivedi S, Kleeberger S . Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol. 2008; 122(3):456-68. PMC: 2693323. DOI: 10.1016/j.jaci.2008.08.004. View

Wang J, Ueng T, Lin J . Biochemical and morphological alterations in the lungs and livers of mice following exposure to polluted air in a traffic tunnel. Proc Natl Sci Counc Repub China B. 1992; 16(2):77-83. View

Medbo A, Melbye H . Lung function testing in the elderly--can we still use FEV1/FVC<70% as a criterion of COPD?. Respir Med. 2007; 101(6):1097-105. DOI: 10.1016/j.rmed.2006.11.019. View

. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med. 1995; 152(3):1107-36. DOI: 10.1164/ajrccm.152.3.7663792. View

10.

Liu S, Zhou Y, Liu S, Chen X, Zou W, Zhao D . Association between exposure to ambient particulate matter and chronic obstructive pulmonary disease: results from a cross-sectional study in China. Thorax. 2016; 72(9):788-795. PMC: 5738534. DOI: 10.1136/thoraxjnl-2016-208910. View

11.

Probst-Hensch N, Curjuric I, Pierre-Olivier B, Ackermann-Liebrich U, Bettschart R, Brandli O . Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort. Thorax. 2009; 65(2):150-6. DOI: 10.1136/thx.2009.115063. View

12.

Eckel S, Louis T, Chaves P, Fried L, Margolis A . Modification of the association between ambient air pollution and lung function by frailty status among older adults in the Cardiovascular Health Study. Am J Epidemiol. 2012; 176(3):214-23. PMC: 3491964. DOI: 10.1093/aje/kws001. View

13.

Lamichhane D, Kim H, Choi C, Shin M, Shim Y, Leem J . Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study. Yonsei Med J. 2017; 58(6):1111-1118. PMC: 5653475. DOI: 10.3349/ymj.2017.58.6.1111. View

14.

Rice M, Ljungman P, Wilker E, Dorans K, Gold D, Schwartz J . Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham heart study. Am J Respir Crit Care Med. 2015; 191(6):656-64. PMC: 4384780. DOI: 10.1164/rccm.201410-1875OC. View

15.

Cakmak S, Hebbern C, Cakmak J, Vanos J . The modifying effect of socioeconomic status on the relationship between traffic, air pollution and respiratory health in elementary schoolchildren. J Environ Manage. 2016; 177:1-8. DOI: 10.1016/j.jenvman.2016.03.051. View

16.

Kesavachandran C, Bihari V, Pangtey B, Kamal R, Singh A, Srivastava A . Gender Disparity in Lung Function Abnormalities among a Population Exposed to Particulate Matter Concentration in Ambient Air in the National Capital Region, India. J Health Pollut. 2018; 5(9):47-60. PMC: 6221490. DOI: 10.5696/2156-9614-5-9.47. View

17.

Paulose-Ram R, Tilert T, Dillon C, Brody D . Cigarette smoking and lung obstruction among adults aged 40-79: United States, 2007-2012. NCHS Data Brief. 2015; (181):1-8. View

18.

Pujades-Rodriguez M, McKeever T, Lewis S, Whyatt D, Britton J, Venn A . Effect of traffic pollution on respiratory and allergic disease in adults: cross-sectional and longitudinal analyses. BMC Pulm Med. 2009; 9:42. PMC: 2744653. DOI: 10.1186/1471-2466-9-42. View

19.

Kubesch N, de Nazelle A, Westerdahl D, Martinez D, Carrasco-Turigas G, Bouso L . Respiratory and inflammatory responses to short-term exposure to traffic-related air pollution with and without moderate physical activity. Occup Environ Med. 2014; 72(4):284-93. DOI: 10.1136/oemed-2014-102106. View

20.

Forbes L, Kapetanakis V, Rudnicka A, Cook D, Bush T, Stedman J . Chronic exposure to outdoor air pollution and lung function in adults. Thorax. 2009; 64(8):657-63. DOI: 10.1136/thx.2008.109389. View