Toward the Relevance of Platelet Subpopulations for Transfusion Medicine

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2018 Feb 21

PMID 29459897

Citations 17

Authors

Stefan Handtke

Leif Steil

Andreas Greinacher

Thomas Thiele

Affiliations

Soon will be listed here.

Abstract

Circulating platelets consist of subpopulations with different age, maturation state and size. In this review, we address the association between platelet size and platelet function and summarize the current knowledge on platelet subpopulations including reticulated platelets, procoagulant platelets and platelets exposing signals to mediate their clearance. Thereby, we emphasize the impact of platelet turnover as an important condition for platelet production . Understanding of the features that characterize platelet subpopulations is very relevant for the methods of platelet concentrate production, which may enrich or deplete particular platelet subpopulations. Moreover, the concept of platelet size being associated with platelet function may be attractive for transfusion medicine as it holds the perspective to separate platelet subpopulations with specific functional capabilities.

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