Neuromodulation Via the Cerebrospinal Fluid: Insights from Recent Studies

Overview

Journal Front Neural Circuits

Date 2018 Feb 21

PMID 29459822

Citations 11

Authors

Andreas Bjorefeldt

Sebastian Illes

Henrik Zetterberg

Eric Hanse

Affiliations

Soon will be listed here.

Abstract

The cerebrospinal fluid (CSF) occupies the brain's ventricles and subarachnoid space and, together with the interstitial fluid (ISF), forms a continuous fluidic network that bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned to actively distribute neuromodulators to neural circuits via volume transmission. Recent experimental work in brain slices and neuronal cultures has shown that human CSF indeed contains neuromodulators that strongly influence neuronal activity. Here we briefly summarize these new findings and discuss their potential relevance to neural circuits in health and disease.

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