Associations Between Gene Polymorphisms and Coronary Artery Disease: Evidence Based on an Updated and Cumulative Meta-analysis

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 Feb 21

PMID 29459423

Citations 7

Authors

Wen-Qi Ma

Ying Wang

Xi-Qiong Han

Yi Zhu

Nai-Feng Liu

Affiliations

Soon will be listed here.

Abstract

Lipoprotein lipase (LPL) is widely linked to lipid and lipoprotein metabolism, but its effects on coronary artery disease (CAD) are not clearly elucidated. The aim of this study was to clarify the association between gene polymorphisms and CAD susceptibility. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated to estimate the strength of the relationship between gene polymorphisms and CAD risk. Comprehensive electronic databases, including PubMed, EMBASE, Web of Science, and the Cochrane Library, were systematically searched. A total of 45 records containing 80 eligible studies were analyzed. The results indicated an increased risk between the D9N polymorphism and susceptibility to CAD in the dominant genetic model (AA + GA vs. GG: OR = 1.46, 95% CI = 1.14-1.87), whereas the HindIII polymorphism showed a protective effect against CAD under all tested models (GG+GT vs. TT: OR = 0.85, 95% CI = 0.75-0.97; GG vs. TT + TG: OR = 0.62, 95% CI = 0.47-0.83; G vs. T: OR = 0.81, 95% CI = 0.71-0.92). No significant association was identified for the N291S and PvuII polymorphisms. Stratification analysis by ethnicity suggested a significant correlation between the S447X polymorphism and CAD susceptibility in Caucasians under the dominant and allele genetic models. In summary, our meta-analysis indicated that the D9N polymorphism was associated with an increased risk of CAD, whereas the S447X and HindIII polymorphisms showed protective effects. There was no association observed between the N291S and PvuII polymorphisms and CAD risk.

Citing Articles

Associations of the PPARα and Lipoprotein Lipase Enzyme Gene Polymorphisms with Dyslipidemia in Obese and Non-obese Males.

Al-Samawi R, Al-Kashwan T, Algenabi A J Obes Metab Syndr. 2024; 33(3):213-221.

PMID: 39098051 PMC: 11443331. DOI: 10.7570/jomes23064.

Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome.

Butnariu L, Gorduza E, Tarca E, Panzaru M, Popa S, Stoleriu S Diagnostics (Basel). 2023; 13(14).

PMID: 37510094 PMC: 10378477. DOI: 10.3390/diagnostics13142348.

Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?.

Butnariu L, Florea L, Badescu M, Tarca E, Costache I, Gorduza E Life (Basel). 2022; 12(6).

PMID: 35743896 PMC: 9225091. DOI: 10.3390/life12060865.

Genetic Variants of Lipoprotein Lipase and Regulatory Factors Associated with Alzheimer's Disease Risk.

Bruce K, Tang M, Reigan P, Eckel R Int J Mol Sci. 2020; 21(21).

PMID: 33172164 PMC: 7664401. DOI: 10.3390/ijms21218338.

Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population.

Bogari N, Aljohani A, Dannoun A, Elkhateeb O, Porqueddu M, Amin A Saudi J Biol Sci. 2020; 27(8):2018-2024.

PMID: 32714026 PMC: 7376116. DOI: 10.1016/j.sjbs.2020.06.029.

References

Clee S, Bissada N, Miao F, Miao L, Marais A, Henderson H . Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. J Lipid Res. 2000; 41(4):521-31. View

Preiss-Landl K, Zimmermann R, Hammerle G, Zechner R . Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. Curr Opin Lipidol. 2002; 13(5):471-81. DOI: 10.1097/00041433-200210000-00002. View

Sparkes R, Zollman S, Klisak I, Kirchgessner T, Komaromy M, Mohandas T . Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21. Genomics. 1987; 1(2):138-44. DOI: 10.1016/0888-7543(87)90005-x. View

Sawano M, Watanabe Y, Ohmura H, Shimada K, Daida H, Mokuno H . Potentially protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile. Jpn Circ J. 2001; 65(4):310-4. DOI: 10.1253/jcj.65.310. View

Peacock R, Hamsten A, Nilsson-Ehle P, Humphries S . Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden. Atherosclerosis. 1992; 97(2-3):171-85. DOI: 10.1016/0021-9150(92)90130-9. View

van Bockxmeer F, Liu Q, Mamotte C, Burke V, Taylor R . Lipoprotein lipase D9N, N291S and S447X polymorphisms: their influence on premature coronary heart disease and plasma lipids. Atherosclerosis. 2001; 157(1):123-9. DOI: 10.1016/s0021-9150(00)00717-6. View

Abd-El-Aziz T, Mohamed R, El-Shal A . Synergistic effect between lipoprotein lipase and apolipoprotein C3 genes in determining the severity of coronary artery disease. J Cardiovasc Transl Res. 2013; 6(3):430-5. DOI: 10.1007/s12265-013-9446-3. View

Stepanov V, Puzyrev V, Karpov R, Kutmin A . Genetic markers in coronary artery disease in a Russian population. Hum Biol. 1998; 70(1):47-57. View

Izar M, Helfenstein T, Ihara S, Relvas W, Santos A, Fischer S . Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study. Atherosclerosis. 2008; 204(1):165-70. DOI: 10.1016/j.atherosclerosis.2008.08.006. View

10.

Susleyici Duman B, Turkoglu C, Akpinar B, Guden M, Vertii A, Dak E . Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease. Arch Pathol Lab Med. 2004; 128(8):869-74. DOI: 10.5858/2004-128-869-LLGPAL. View

11.

Keavney B, Palmer A, Parish S, Clark S, Youngman L, Danesh J . Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk. Int J Epidemiol. 2004; 33(5):1002-13. DOI: 10.1093/ije/dyh275. View

12.

Sagoo G, Tatt I, Salanti G, Butterworth A, Sarwar N, van Maarle M . Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. Am J Epidemiol. 2008; 168(11):1233-46. DOI: 10.1093/aje/kwn235. View

13.

Holmer S, Hengstenberg C, Mayer B, Doring A, Lowel H, Engel S . Lipoprotein lipase gene polymorphism, cholesterol subfractions and myocardial infarction in large samples of the general population. Cardiovasc Res. 2000; 47(4):806-12. DOI: 10.1016/s0008-6363(00)00131-0. View

14.

Wittrup H, Tybjaerg-Hansen A, Nordestgaard B . Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis. Circulation. 1999; 99(22):2901-7. DOI: 10.1161/01.cir.99.22.2901. View

15.

Toth P . Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease. Vasc Health Risk Manag. 2016; 12:171-83. PMC: 4866746. DOI: 10.2147/VHRM.S104369. View

16.

Baum L, Ng H, Wong K, Tomlinson B, Rainer T, Chen X . Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction. Clin Chem Lab Med. 2006; 44(3):274-81. DOI: 10.1515/CCLM.2006.047. View

17.

AshokKumar M, Veera Subhashini N, Kanthimathi S, Saibabu R, Ramesh A, Cherian K . Associations for lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene and coronary artery disease in an Indian population. Arch Med Res. 2010; 41(1):19-25.e1. DOI: 10.1016/j.arcmed.2010.01.005. View

18.

Myllykangas L, Polvikoski T, Sulkava R, Notkola I, Rastas S, Verkkoniemi A . Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study. Ann Med. 2001; 33(7):486-92. DOI: 10.3109/07853890109002098. View

19.

Wang X, MCCREDIE R, Wilcken D . Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes. Circulation. 1996; 93(7):1339-45. DOI: 10.1161/01.cir.93.7.1339. View

20.

Zhang Q, Cavanna J, Winkelman B, Shine B, Gross W, Marz W . Common genetic variants of lipoprotein lipase that relate to lipid transport in patients with premature coronary artery disease. Clin Genet. 1995; 48(6):293-8. DOI: 10.1111/j.1399-0004.1995.tb04112.x. View