Magnetic Resonance Elastography to Estimate Brain Stiffness: Measurement Reproducibility and Its Estimate in Pseudotumor Cerebri Patients

Overview

Journal Clin Imaging

Publisher Elsevier

Specialty Radiology

Date 2018 Feb 21

PMID 29459315

Citations 14

Authors

Arunark Kolipaka

Peter A Wassenaar

Sangmin Cha

Wael M Marashdeh

Xiaokui Mo

Prateek Kalra

Bradley Gans

Brian Raterman

Eric Bourekas

Affiliations

Soon will be listed here.

Abstract

This study determines the reproducibility of magnetic resonance elastography (MRE) derived brain stiffness in normal volunteers and compares it against pseudotumor patients before and after lumbar puncture (LP). MRE was performed on 10 normal volunteers for reproducibility and 14 pseudotumor patients before and after LP. During LP, opening and closing cerebrospinal fluid (CSF) pressures were recorded before and after removal of CSF and correlated to brain stiffness. Stiffness reproducibility was observed (r > 0.78; p < 0.008). Whole brain opening LP stiffness was significantly (p = 0.04) higher than normals, but no significant difference (p = 0.11) in closing LP measurements. No significant correlation was observed between opening and closing pressure and brain stiffness.

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