The Root Aqueous Extract of Guill. Et Perr. (Mimosaceae) Inhibits Implant Growth, Alleviates Dysmenorrhea, and Restores Ovarian Dynamic in a Rat Model of Endometriosis

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2018 Feb 20

PMID 29456574

Citations 6

Authors

Marie Alfrede Mvondo

Stephane Minko Essono

Francis Desire Bomba Tatsinkou

Sylvin Benjamin Ateba

Dieudonne Njamen

Affiliations

Soon will be listed here.

Abstract

(Mimosaceae) was reported to have analgesic and antioxidant properties. The present study is aimed at investigating the effects of the root aqueous extract of (EA) on an experimental model of endometriosis. The study was performed in rats orally treated with EA at doses of 127.5, 255, and 510 mg/kg. Microgynon® 30 served as the reference substance. Estradiol valerate and oxytocin were used to induce dysmenorrhea. Endometrial implant levels of catalase and malondialdehyde (MDA) allowed estimating tissue oxidative status. Ovarian dynamic and rat sexual behavior were assessed through histological analysis of ovaries, uterus, and vagina. EA decreased dysmenorrhea at tested doses following a 7-day treatment ( < 0.001). Endometrial implant volume decreased following the three treatment periods ( < 0.05). Catalase activity ( < 0.001) and MDA level ( < 0.01) increased only following a 3-day treatment. EA also increased antral follicles, reduced luteinized unruptured follicle number ( < 0.001), and induced animals to be in the estrus phase. In conclusion, EA prevented the progress of endometriosis, reduced dysmenorrhea, promoted ovarian follicle growth, prevented anovulation, and stimulated the special period of rat sexual desire. These results suggest that could be a promising alternative option for the treatment of endometriosis.

Citing Articles

Murine Models and Research Progress on Dysmenorrhea.

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The effectiveness of antioxidant therapy (vitamin C) in an experimentally induced mouse model of ovarian endometriosis.

Hoorsan H, Simbar M, Ramezani Tehrani F, Fathi F, Mosaffa N, Riazi H Womens Health (Lond). 2022; 18:17455057221096218.

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The leaf aqueous extract of Myrianthus arboreus P. Beauv. (Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.

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The Ethanol Extract of Avocado ( Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis.

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