Scratching the Surface of Werner Syndrome and Human Ageing

Overview

Journal Mol Syndromol

Date 2018 Feb 20

PMID 29456476

Citations 1

Authors

Martin Poot

Affiliations

Soon will be listed here.

Citing Articles

Werner's Syndrome: Understanding the Phenotype of Premature Aging-First Case Described in Colombia.

Rincon A, Mora L, Suarez-Obando F, Rojas J Case Rep Genet. 2019; 2019:8538325.

PMID: 30891318 PMC: 6390251. DOI: 10.1155/2019/8538325.

References

Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P . DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells. J Biol Chem. 2014; 289(39):27314-27326. PMC: 4175362. DOI: 10.1074/jbc.M114.578823. View

Poot M, Haaf T . Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements. Mol Syndromol. 2016; 6(3):110-34. PMC: 4698629. DOI: 10.1159/000438812. View

Maierhofer A, Flunkert J, Oshima J, Martin G, Haaf T, Horvath S . Accelerated epigenetic aging in Werner syndrome. Aging (Albany NY). 2017; 9(4):1143-1152. PMC: 5425119. DOI: 10.18632/aging.101217. View

Poot M, Verkerk A, Koster J, JONGKIND J . De novo synthesis of glutathione in human fibroblasts during in vitro ageing and in some metabolic diseases as measured by a flow cytometric method. Biochim Biophys Acta. 1986; 883(3):580-4. DOI: 10.1016/0304-4165(86)90300-4. View

Ogburn C, Oshima J, Poot M, Chen R, Hunt K, Gollahon K . An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet. 1997; 101(2):121-5. DOI: 10.1007/s004390050599. View

Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S . Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2012; 49(2):359-367. PMC: 3780611. DOI: 10.1016/j.molcel.2012.10.016. View

Salk D, Au K, Hoehn H, Martin G . Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet. 1981; 30(2):92-107. DOI: 10.1159/000131596. View

Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J . Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015; 348(6239):1160-3. PMC: 4494668. DOI: 10.1126/science.aaa1356. View

Kirkwood T, Cremer T . Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum Genet. 1982; 60(2):101-21. DOI: 10.1007/BF00569695. View

10.

Poot M . Oxidants and antioxidants in proliferative senescence. Mutat Res. 1991; 256(2-6):177-89. DOI: 10.1016/0921-8734(91)90010-9. View

11.

Kamath-Loeb A, Zavala-van Rankin D, Flores-Morales J, Emond M, Sidorova J, Carnevale A . Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype. Sci Rep. 2017; 7:44081. PMC: 5343477. DOI: 10.1038/srep44081. View

12.

Bocklandt S, Lin W, Sehl M, Sanchez F, Sinsheimer J, Horvath S . Epigenetic predictor of age. PLoS One. 2011; 6(6):e14821. PMC: 3120753. DOI: 10.1371/journal.pone.0014821. View

13.

Poot M, Gollahon K, Rabinovitch P . Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase. Hum Genet. 1999; 104(1):10-4. DOI: 10.1007/s004390050903. View

14.

Poot M, Verkerk A, JONGKIND J . Glutathione content of cultured human fibroblasts during in vitro ageing. Mech Ageing Dev. 1984; 27(3):315-21. DOI: 10.1016/0047-6374(84)90055-1. View

15.

Garagnani P, Bacalini M, Pirazzini C, Gori D, Giuliani C, Mari D . Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell. 2012; 11(6):1132-4. DOI: 10.1111/acel.12005. View

16.

Poot M, Hoehn H, Runger T, Martin G . Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res. 1992; 202(2):267-73. DOI: 10.1016/0014-4827(92)90074-i. View

17.

Raes M, Michiels C, Remacle J . Comparative study of the enzymatic defense systems against oxygen-derived free radicals: the key role of glutathione peroxidase. Free Radic Biol Med. 1987; 3(1):3-7. DOI: 10.1016/0891-5849(87)90032-3. View

18.

Fukuchi K, Martin G, Monnat Jr R . Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci U S A. 1989; 86(15):5893-7. PMC: 297737. DOI: 10.1073/pnas.86.15.5893. View

19.

Guastafierro T, Bacalini M, Marcoccia A, Gentilini D, Pisoni S, Di Blasio A . Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome. Clin Epigenetics. 2017; 9:92. PMC: 5577832. DOI: 10.1186/s13148-017-0389-4. View

20.

Rabinovitch P . Regulation of human fibroblast growth rate by both noncycling cell fraction transition probability is shown by growth in 5-bromodeoxyuridine followed by Hoechst 33258 flow cytometry. Proc Natl Acad Sci U S A. 1983; 80(10):2951-5. PMC: 393951. DOI: 10.1073/pnas.80.10.2951. View