Nutraceuticals As Therapeutic Agents for Atherosclerosis

Overview

Journal Biochim Biophys Acta Mol Basis Dis

Publisher Elsevier

Specialties Biochemistry
Biophysics
Genetics
Molecular Biology

Date 2018 Feb 18

PMID 29454074

Citations 26

Authors

Joe W E Moss

Jessica O Williams

Dipak P Ramji

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an underlying cause of cardiovascular disease (CVD), is responsible for a third of all global deaths. Current treatments for CVD, such as optimized statin therapy, are associated with considerable residual risk and several side effects in some patients. The outcome of research on the identification of alternative pharmaceutical agents for the treatment of CVD has been relatively disappointing with many promising leads failing at the clinical level. Nutraceuticals, products from food sources with health benefits beyond their nutritional value, represent promising agents in the prevention of CVD or as an add-on therapy with current treatments. This review will highlight the potential of several nutraceuticals, including polyunsaturated fatty acids, flavonoids and other polyphenols, as anti-CVD therapies based on clinical and pre-clinical mechanism-based studies.

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References

Tjelle T, Holtung L, Bohn S, Aaby K, Thoresen M, Wiik S . Polyphenol-rich juices reduce blood pressure measures in a randomised controlled trial in high normal and hypertensive volunteers. Br J Nutr. 2015; 114(7):1054-63. DOI: 10.1017/S0007114515000562. View

Oh K, Hu F, Manson J, Stampfer M, Willett W . Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study. Am J Epidemiol. 2005; 161(7):672-9. DOI: 10.1093/aje/kwi085. View

Shin S, Ha T, McGregor R, Choi M . Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Mol Nutr Food Res. 2011; 55(12):1829-40. DOI: 10.1002/mnfr.201100440. View

Bays H, Ballantyne C, Braeckman R, Stirtan W, Soni P . Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the MARINE and ANCHOR studies. Am J Cardiovasc Drugs. 2013; 13(1):37-46. PMC: 3572383. DOI: 10.1007/s40256-012-0002-3. View

Ravera A, Carubelli V, Sciatti E, Bonadei I, Gorga E, Cani D . Nutrition and Cardiovascular Disease: Finding the Perfect Recipe for Cardiovascular Health. Nutrients. 2016; 8(6). PMC: 4924204. DOI: 10.3390/nu8060363. View

Tresserra-Rimbau A, Rimm E, Medina-Remon A, Martinez-Gonzalez M, de la Torre R, Corella D . Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study. Nutr Metab Cardiovasc Dis. 2014; 24(6):639-47. DOI: 10.1016/j.numecd.2013.12.014. View

Chan Y, El-Nezami H, Chen Y, Kinnunen K, Kirjavainen P . Probiotic mixture VSL#3 reduce high fat diet induced vascular inflammation and atherosclerosis in ApoE(-/-) mice. AMB Express. 2016; 6(1):61. PMC: 5005234. DOI: 10.1186/s13568-016-0229-5. View

Liu C, Zheng Y, Zhang Y, Long X . Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia. 2016; 109:274-82. DOI: 10.1016/j.fitote.2016.02.001. View

Sansone R, Rodriguez-Mateos A, Heuel J, Falk D, Schuler D, Wagstaff R . Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. Br J Nutr. 2015; 114(8):1246-55. PMC: 4594054. DOI: 10.1017/S0007114515002822. View

10.

Barski O, Xie Z, Baba S, Sithu S, Agarwal A, Cai J . Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2013; 33(6):1162-70. PMC: 3869200. DOI: 10.1161/ATVBAHA.112.300572. View

11.

Mulvihill E, Burke A, Huff M . Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis. Annu Rev Nutr. 2016; 36:275-99. DOI: 10.1146/annurev-nutr-071715-050718. View

12.

Merchant A, Hu F, Spiegelman D, Willett W, Rimm E, Ascherio A . Dietary fiber reduces peripheral arterial disease risk in men. J Nutr. 2003; 133(11):3658-63. DOI: 10.1093/jn/133.11.3658. View

13.

Huang Y, Wang J, Quan G, Wang X, Yang L, Zhong L . Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice. Appl Environ Microbiol. 2014; 80(24):7496-504. PMC: 4249224. DOI: 10.1128/AEM.02926-14. View

14.

Brown B, Kim C, Torpy F, Bursill C, McRobb L, Heather A . Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E(-/-) mice. Atherosclerosis. 2014; 232(2):403-9. DOI: 10.1016/j.atherosclerosis.2013.11.068. View

15.

Ramkumar S, Raghunath A, Raghunath S . Statin Therapy: Review of Safety and Potential Side Effects. Acta Cardiol Sin. 2016; 32(6):631-639. PMC: 5126440. DOI: 10.6515/acs20160611a. View

16.

Wongwarawipat T, Papageorgiou N, Bertsias D, Siasos G, Tousoulis D . Olive Oil-related Anti-inflammatory Effects on Atherosclerosis: Potential Clinical Implications. Endocr Metab Immune Disord Drug Targets. 2017; 18(1):51-62. DOI: 10.2174/1871530317666171116103618. View

17.

Karppi J, Kurl S, Laukkanen J, Rissanen T, Kauhanen J . Plasma carotenoids are related to intima--media thickness of the carotid artery wall in men from eastern Finland. J Intern Med. 2011; 270(5):478-85. DOI: 10.1111/j.1365-2796.2011.02401.x. View

18.

West S, McIntyre M, Piotrowski M, Poupin N, Miller D, Preston A . Effects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adults. Br J Nutr. 2013; 111(4):653-61. DOI: 10.1017/S0007114513002912. View

19.

Panahi Y, Hosseini M, Khalili N, Naimi E, Majeed M, Sahebkar A . Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr. 2015; 34(6):1101-8. DOI: 10.1016/j.clnu.2014.12.019. View

20.

Fan Y, Ramos K, Chapkin R . Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. J Nutr. 2001; 131(6):1675-81. DOI: 10.1093/jn/131.6.1675. View