Cough Hypersensitivity in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

Overview

Journal Sleep Breath

Publisher Springer

Date 2018 Feb 18

PMID 29453637

Citations 8

Authors

Cuiqin Shi

Siwei Liang

Xianghuai Xu

Qiang Chen

Lan Wang

Li Yu

Hanjing Lv

Zhongmin Qiu

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of this study was to investigate cough hypersensitivity and its potential mechanisms in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).

Methods: Fifteen OSAHS patients, 12 simple snoring patients, and 15 healthy volunteers received cough sensitivity test and induced sputum cytology. Cough thresholds C2 and C5 (the minimum of capsaicin inducing ≥ 2 and ≥ 5 coughs, respectively), total cell count, cell differentials and the levels of bradykinin, histamine, prostaglandin E, substance P, calcitonin gene-related peptide, pepsin, and interleukin-2 in the induced sputum detected by enzyme-linked immunosorbent assay were compared. The linear correlation between lgC2 and lgC5 and apnea hypopnea index, cell differentials, and inflammatory mediators in the induced sputum was calculated in OSAHS patients.

Results: OSAHS patients presented with a significant lower C2 and C5 (P < 0.01), increased lymphocyte but decreased macrophage and neutrophil proportions in the induced sputum (P < 0.01), and higher contents of substance P, calcitonin gene-related peptide and interleukin-2 (P < 0.01) but similar levels of bradykinin, pepsin, prostaglandin E, and histamine (P > 0.05) in the supernatant of induced sputum, when compared with simple snoring patients and healthy volunteers. However, theses variable were comparable between simple snoring patients and healthy volunteers (P > 0.05). Finally, lgC2 or lgC5 was negatively related to apnea hypopnea index, lymphocyte percentage, and the levels of substance P, calcitonin gene-related peptide or interleukin-2 in the sputum (P < 0.01). There was a positive linear correlation between lymphocyte percentage and interleukin-2 level in the induced sputum (r = 0.63, P = 0.00).

Conclusion: OSAHS patients have a predisposition of cough hypersensitivity associated with airway inflammation.

Citing Articles

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Evaluation methods and influencing factors of cough sensitivity.

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Su J, Fang Y, Meng Y, Zhao C, Liu Y, Sun L Nat Sci Sleep. 2022; 14:13-23.

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Utility of Cough Provocation Tests in Chronic Cough and Respiratory Diseases: A Comprehensive Review and Introduction of New Reference Ranges for the Capsaicin Test.

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Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms.

Cheng J, Xie Z, Wang S, Wen S, Niu S, Shi C BMC Pulm Med. 2021; 21(1):284.

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