Sequential Analysis in Neonatal Research-systematic Review

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2018 Feb 18

PMID 29453599

Citations 3

Authors

Sebastiano A G Lava

Valery Elie

Phuong Thi Viet Ha

Evelyne Jacqz-Aigrain

Affiliations

Soon will be listed here.

Abstract

Conclusion: Sequential trial designs have not been frequently used in Neonatology. They might potentially be able to reduce the number of patients in drug trials, although this is not always the case. What is known: • In evaluating rare diseases in fragile populations, traditional designs come at their limits. About 20% of pediatric trials are discontinued, mainly because of recruitment problems. What is new: • Sequential trials involving newborns were infrequently used and only a few (n = 21) are available for analysis. • The sequential design allowed to non-significantly reduce the number of enrolled neonates by a median of 24 (31%) patients (IQR - 4.75 to 136.5, p = 0.0674).

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