Evidence of a Gene-environment Interaction of NODAL Variants and Inflammation in Preterm Birth

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2018 Feb 18

PMID 29453435

Citations 1

Authors

Lisa M Starr

Taghreed A Ayash

Daniel Dufort

Affiliations

Soon will be listed here.

Abstract

Objective: NODAL has been implicated in timing of parturition and immune regulation. We investigated the relationship between NODAL polymorphisms, infection/inflammation, and preterm birth.

Study Design: For this secondary analysis, 613 women (189 preterm and 424 term) from the Montreal Prematurity Study were genotyped for NODAL polymorphisms and assessed for bacterial vaginosis and placental inflammation.

Result: NODAL polymorphisms were not associated with preterm birth. However, the rs2231947(C>T) variant allele was associated with increased risk for preterm birth among women with bacterial vaginosis (odds ratio: 2.76, 95% confidence interval: 1.12-6.85). Among women without placental inflammation, the rs1904589(A>G) variant allele was associated with increased risk of preterm birth (odds ratio: 1.31, 95% confidence interval: 1.02-1.70). Among women with placental inflammation, the rs10999338(C>T) variant allele was associated with reduced risk of preterm birth (odds ratio: 0.50, 95% confidence interval: 0.29-0.87).

Conclusion: The effect of NODAL polymorphisms on preterm birth depends on maternal infection/inflammation status.

Citing Articles

Uterine Nodal expression supports maternal immunotolerance and establishment of the FOXP3 regulatory T cell population during the preimplantation period.

Yull S, Shafiei S, Park C, Kazemi P, Tiemann E, Godin Page M Front Immunol. 2023; 14:1276979.

PMID: 38022561 PMC: 10646213. DOI: 10.3389/fimmu.2023.1276979.

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