Decreased Anterior Cingulate Activation in a Motor Task in Youths with Bipolar Disorder

Overview

Journal J Child Psychol Psychiatry

Specialties Psychiatry
Psychology

Date 2018 Feb 17

PMID 29451300

Citations 4

Authors

Jace B King

Jeffrey S Anderson

Deborah A Yurgelun-Todd

Punitha Subramaniam

Marie R Ehrler

Melissa P Lopez-Larson

Affiliations

Soon will be listed here.

Abstract

Background: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task.

Methods: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between-group whole-brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole-brain false discovery rate (FDR) correction (qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention-deficit/hyperactivity disorder (ADHD) in the BP group were also conducted.

Results: Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP.

Conclusions: These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP.

Citing Articles

Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.

Colic L, Sankar A, Goldman D, Kim J, Blumberg H Mol Psychiatry. 2024; 30(3):1089-1101.

PMID: 39333385 PMC: 11835756. DOI: 10.1038/s41380-024-02758-4.

Functional Connectivity of the Anterior Cingulate Cortex and the Right Anterior Insula Differentiates between Major Depressive Disorder, Bipolar Disorder and Healthy Controls.

Todeva-Radneva A, Kandilarova S, Paunova R, Stoyanov D, Zdravkova T, Sladky R Biomedicines. 2023; 11(6).

PMID: 37371703 PMC: 10296271. DOI: 10.3390/biomedicines11061608.

Cognitive impairment in bipolar disorder in comparison to mild cognitive impairment and dementia: a systematic review.

Simjanoski M, McIntyre A, Kapczinski F, de Azevedo Cardoso T Trends Psychiatry Psychother. 2021; 44.

PMID: 34374270 PMC: 10039729. DOI: 10.47626/2237-6089-2021-0300.

Structural Changes Induced by Acupuncture in the Recovering Brain after Ischemic Stroke.

Wu P, Zhou Y, Liao C, Tang Y, Li Y, Qiu L Evid Based Complement Alternat Med. 2018; 2018:5179689.

PMID: 29951105 PMC: 5989285. DOI: 10.1155/2018/5179689.

References

Weathers J, Stringaris A, Deveney C, Brotman M, Zarate Jr C, Connolly M . A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder. Am J Psychiatry. 2012; 169(6):633-41. PMC: 3466815. DOI: 10.1176/appi.ajp.2012.11081244. View

Gruber S, Rogowska J, Yurgelun-Todd D . Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord. 2004; 82(2):191-201. DOI: 10.1016/j.jad.2003.10.010. View

Frankland A, Cerrillo E, Hadzi-Pavlovic D, Roberts G, Wright A, Loo C . Comparing the phenomenology of depressive episodes in bipolar I and II disorder and major depressive disorder within bipolar disorder pedigrees. J Clin Psychiatry. 2015; 76(1):32-8. DOI: 10.4088/JCP.14m09293. View

Sobin C, Mayer L, Endicott J . The motor agitation and retardation scale: a scale for the assessment of motor abnormalities in depressed patients. J Neuropsychiatry Clin Neurosci. 1998; 10(1):85-92. DOI: 10.1176/jnp.10.1.85. View

Skirrow C, McLoughlin G, Kuntsi J, Asherson P . Behavioral, neurocognitive and treatment overlap between attention-deficit/hyperactivity disorder and mood instability. Expert Rev Neurother. 2009; 9(4):489-503. DOI: 10.1586/ern.09.2. View

Dickstein D, Gorrostieta C, Ombao H, Goldberg L, Brazel A, Gable C . Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder. Biol Psychiatry. 2010; 68(9):839-46. PMC: 2955843. DOI: 10.1016/j.biopsych.2010.06.029. View

Mostofsky S, Rimrodt S, Schafer J, Boyce A, Goldberg M, Pekar J . Atypical motor and sensory cortex activation in attention-deficit/hyperactivity disorder: a functional magnetic resonance imaging study of simple sequential finger tapping. Biol Psychiatry. 2005; 59(1):48-56. DOI: 10.1016/j.biopsych.2005.06.011. View

Chang K, Adleman N, Dienes K, Simeonova D, Menon V, Reiss A . Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Arch Gen Psychiatry. 2004; 61(8):781-92. DOI: 10.1001/archpsyc.61.8.781. View

Marchand W, Lee J, Thatcher J, Thatcher G, Jensen C, Starr J . A preliminary longitudinal fMRI study of frontal-subcortical circuits in bipolar disorder using a paced motor activation paradigm. J Affect Disord. 2007; 103(1-3):237-41. DOI: 10.1016/j.jad.2007.01.008. View

10.

Marchand W, Lee J, Thatcher G, Jensen C, Stewart D, Dilda V . A functional MRI study of a paced motor activation task to evaluate frontal-subcortical circuit function in bipolar depression. Psychiatry Res. 2007; 155(3):221-30. DOI: 10.1016/j.pscychresns.2007.03.003. View

11.

Young R, Biggs J, Ziegler V, Meyer D . A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978; 133:429-35. DOI: 10.1192/bjp.133.5.429. View

12.

Althoff R, Rettew D, Ayer L, Hudziak J . Cross-informant agreement of the Dysregulation Profile of the Child Behavior Checklist. Psychiatry Res. 2010; 178(3):550-5. PMC: 2914203. DOI: 10.1016/j.psychres.2010.05.002. View

13.

Joshi G, Wilens T . Comorbidity in pediatric bipolar disorder. Child Adolesc Psychiatr Clin N Am. 2009; 18(2):291-319, vii-viii. PMC: 3757953. DOI: 10.1016/j.chc.2008.12.005. View

14.

Bush , Luu , Posner . Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci. 2000; 4(6):215-222. DOI: 10.1016/s1364-6613(00)01483-2. View

15.

Singh M, Kelley R, Chang K, Gotlib I . Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder. J Am Acad Child Adolesc Psychiatry. 2015; 54(9):763-70. PMC: 4548854. DOI: 10.1016/j.jaac.2015.06.016. View

16.

Poznanski E, Grossman J, Buchsbaum Y, Banegas M, Freeman L, Gibbons R . Preliminary studies of the reliability and validity of the children's depression rating scale. J Am Acad Child Psychiatry. 1984; 23(2):191-7. DOI: 10.1097/00004583-198403000-00011. View

17.

Altshuler L, Bookheimer S, Townsend J, Proenza M, Eisenberger N, Sabb F . Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biol Psychiatry. 2005; 58(10):763-9. DOI: 10.1016/j.biopsych.2005.09.012. View

18.

Adler C, DelBello M, Mills N, Schmithorst V, Holland S, Strakowski S . Comorbid ADHD is associated with altered patterns of neuronal activation in adolescents with bipolar disorder performing a simple attention task. Bipolar Disord. 2006; 7(6):577-88. DOI: 10.1111/j.1399-5618.2005.00257.x. View

19.

Leibenluft E, Rich B, Vinton D, Nelson E, Fromm S, Berghorst L . Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. Am J Psychiatry. 2007; 164(1):52-60. DOI: 10.1176/ajp.2007.164.1.A52. View

20.

Singh M, Chang K, Mazaika P, Garrett A, Adleman N, Kelley R . Neural correlates of response inhibition in pediatric bipolar disorder. J Child Adolesc Psychopharmacol. 2010; 20(1):15-24. PMC: 2835388. DOI: 10.1089/cap.2009.0004. View