Pseudophakic Bullous Keratopathy

Overview

Journal Rom J Ophthalmol

Specialty Ophthalmology

Date 2018 Feb 17

PMID 29450379

Citations 20

Authors

Stefan Pricopie

Sanziana Istrate

Liliana Voinea

Costin Leasu

Vanessa Paun

Ciuluvica Radu

Affiliations

Soon will be listed here.

Abstract

Pseudophakic bullous keratopathy is characterized by corneal stromal edema with epithelial and subepithelial bullae due to cell loss and endothelial decompensation through trauma during cataract surgery. Patients present decreased vision, tearing, and pain caused by ruptured epithelial bullae. Cataract affects approximately 20 million people worldwide, and this complication can occur in 1 to 2% of the cataract surgeries. This study reviewed the bullous keratopathy etiopathogenesis and the clinical and surgical treatment available for this corneal disease.

Citing Articles

A comparison of endothelial cell count, central corneal thickness and intraocular pressure in different ethnic groups in the Western Cape, South Africa.

Bhika R, Zunza M, Smit D Int Ophthalmol. 2025; 45(1):56.

PMID: 39890681 PMC: 11785701. DOI: 10.1007/s10792-025-03426-4.

Five Year Review of All Examined Corneal Tissue in a Tertiary Eye Care Center: Demographics and Surgical Indications.

Kokandi B, Zahrani S, Helmi H, Alshomar K, Alkatan H J Epidemiol Glob Health. 2024; 14(4):1693-1700.

PMID: 39589451 PMC: 11652461. DOI: 10.1007/s44197-024-00328-z.

Investigating the Tolerance of Corneal Endothelial Cells to Surgical Fluid Pressure Using Intact Porcine Eyes.

McMullen A, Dantsoho Z, Chamness S, Brunelle J, Martiz J, Khalifa Y Transl Vis Sci Technol. 2024; 13(11):27.

PMID: 39570617 PMC: 11585060. DOI: 10.1167/tvst.13.11.27.

Donor Characteristics in Graft Detachment after Posterior Lamellar Keratoplasty for Fuchs Endothelial Dystrophy and Bullous Keratopathy.

Cardascia N, Cassano F, Pastore V, La Tegola M, Sborgia A, Boscia F J Clin Med. 2024; 13(6).

PMID: 38541819 PMC: 10970823. DOI: 10.3390/jcm13061593.

Narrative review after post-hoc trial analysis of factors that predict corneal endothelial cell loss after phacoemulsification: Tips for improving cataract surgery research.

Perone J, Luc M, Zevering Y, Vermion J, Gan G, Goetz C PLoS One. 2024; 19(3):e0298795.

PMID: 38512953 PMC: 10956851. DOI: 10.1371/journal.pone.0298795.

References

Khan M, Basit I, Ishaq M, Shakoor T, Yaqub A, Intisar R . Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. Pak J Med Sci. 2016; 32(4):965-8. PMC: 5017112. DOI: 10.12669/pjms.324.10138. View

Thomann U, Schipper I . Phototherapeutic keratectomy for bullous keratopathy. Br J Ophthalmol. 1995; 79(4):335-8. PMC: 505096. DOI: 10.1136/bjo.79.4.335. View

Reinhart W, Musch D, Jacobs D, Lee W, Kaufman S, Shtein R . Deep anterior lamellar keratoplasty as an alternative to penetrating keratoplasty a report by the american academy of ophthalmology. Ophthalmology. 2011; 118(1):209-18. DOI: 10.1016/j.ophtha.2010.11.002. View

Abud T, Di Zazzo A, Kheirkhah A, Dana R . Systemic Immunomodulatory Strategies in High-risk Corneal Transplantation. J Ophthalmic Vis Res. 2017; 12(1):81-92. PMC: 5340067. DOI: 10.4103/2008-322X.200156. View

Fernandez M, Afshari N . Endothelial Keratoplasty: From DLEK to DMEK. Middle East Afr J Ophthalmol. 2010; 17(1):5-8. PMC: 2880365. DOI: 10.4103/0974-9233.61210. View

Ghanem R, Santhiago M, Berti T, Thomaz S, Netto M . Collagen crosslinking with riboflavin and ultraviolet-A in eyes with pseudophakic bullous keratopathy. J Cataract Refract Surg. 2010; 36(2):273-6. DOI: 10.1016/j.jcrs.2009.07.041. View

Pires R, Tseng S, Prabhasawat P, Puangsricharern V, Maskin S, Kim J . Amniotic membrane transplantation for symptomatic bullous keratopathy. Arch Ophthalmol. 1999; 117(10):1291-7. DOI: 10.1001/archopht.117.10.1291. View

Gomes J, Haraguchi D, Zambrano D, Izquierdo Junior L, Cunha M, de Freitas D . Anterior stromal puncture in the treatment of bullous keratopathy: six-month follow-up. Cornea. 2001; 20(6):570-2. DOI: 10.1097/00003226-200108000-00003. View

Hsu J, Rubinfeld R, Barry P, Jester J . Anterior stromal puncture. Immunohistochemical studies in human corneas. Arch Ophthalmol. 1993; 111(8):1057-63. DOI: 10.1001/archopht.1993.01090080053018. View

10.

Paris F, Goncalves E, De Queiroz Campos M, Sato E, Dua H, Gomes J . Amniotic membrane transplantation versus anterior stromal puncture in bullous keratopathy: a comparative study. Br J Ophthalmol. 2013; 97(8):980-4. DOI: 10.1136/bjophthalmol-2013-303081. View

11.

Siu G, Young A, Jhanji V . Alternatives to corneal transplantation for the management of bullous keratopathy. Curr Opin Ophthalmol. 2014; 25(4):347-52. DOI: 10.1097/ICU.0000000000000062. View

12.

Maini R, Sullivan L, Snibson G, Taylor H, Loughnan M . A comparison of different depth ablations in the treatment of painful bullous keratopathy with phototherapeutic keratectomy. Br J Ophthalmol. 2001; 85(8):912-5. PMC: 1724067. DOI: 10.1136/bjo.85.8.912. View

13.

Goncalves E, Campos M, Paris F, Gomes J, de Farias C . [Bullous keratopathy: etiopathogenesis and treatment]. Arq Bras Oftalmol. 2009; 71(6 Suppl):61-4. DOI: 10.1590/s0004-27492008000700012. View