Lemongrass () Essential Oil Demonstrated Anti-inflammatory Effect in Pre-inflamed Human Dermal Fibroblasts

Overview

Journal Biochim Open

Specialty Biochemistry

Date 2018 Feb 17

PMID 29450147

Citations 20

Authors

Xuesheng Han

Tory L Parker

Affiliations

Soon will be listed here.

Abstract

Lemongrass () essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF). Furthermore, we studied the impact of LEO on genome-wide gene expression profiles. LEO significantly modulated global gene expression and robustly impacted signaling pathways, many of which are critical for inflammation and tissue remodeling processes. This study provides the first evidence of the anti-inflammatory activity of LEO in human skin cells and indicates that it is a good therapeutic candidate for treating inflammatory conditions of the skin.

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References

Amorim J, Simas D, Pinheiro M, Moreno D, Alviano C, Silva A . Anti-Inflammatory Properties and Chemical Characterization of the Essential Oils of Four Citrus Species. PLoS One. 2016; 11(4):e0153643. PMC: 4835072. DOI: 10.1371/journal.pone.0153643. View

Mitoshi M, Kuriyama I, Nakayama H, Miyazato H, Sugimoto K, Kobayashi Y . Suppression of allergic and inflammatory responses by essential oils derived from herbal plants and citrus fruits. Int J Mol Med. 2014; 33(6):1643-51. DOI: 10.3892/ijmm.2014.1720. View

Jiang J, Xu H, Wang H, Zhang Y, Ya P, Yang C . Protective effects of lemongrass essential oil against benzo(a)pyrene-induced oxidative stress and DNA damage in human embryonic lung fibroblast cells. Toxicol Mech Methods. 2016; 27(2):121-127. DOI: 10.1080/15376516.2016.1266541. View

Boukhatem M, Ferhat M, Kameli A, Saidi F, Kebir H . Lemon grass (Cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan J Med. 2014; 9(1):25431. PMC: 4170112. DOI: 10.3402/ljm.v9.25431. View

Han X, Parker T . Arborvitae () essential oil significantly inhibited critical inflammation- and tissue remodeling-related proteins and genes in human dermal fibroblasts. Biochim Open. 2018; 4:56-60. PMC: 5801906. DOI: 10.1016/j.biopen.2017.02.003. View

Song Y, Zhao H, Liu J, Fang C, Miao R . Effects of Citral on Lipopolysaccharide-Induced Inflammation in Human Umbilical Vein Endothelial Cells. Inflammation. 2015; 39(2):663-71. DOI: 10.1007/s10753-015-0292-0. View

Bergamini G, Bell K, Shimamura S, Werner T, Cansfield A, Muller K . A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat Chem Biol. 2012; 8(6):576-82. DOI: 10.1038/nchembio.957. View

Berg E, Yang J, Melrose J, Nguyen D, Privat S, Rosler E . Chemical target and pathway toxicity mechanisms defined in primary human cell systems. J Pharmacol Toxicol Methods. 2009; 61(1):3-15. DOI: 10.1016/j.vascn.2009.10.001. View

Ocheng F, Bwanga F, Bostrom E, Joloba M, Borg-Karlson A, Yucel-Lindberg T . Essential Oils from Ugandan Medicinal Plants: Cytotoxicity and Effects on IL-1-Induced Proinflammatory Mediators by Human Gingival Fibroblasts. Evid Based Complement Alternat Med. 2016; 2016:5357689. PMC: 5078667. DOI: 10.1155/2016/5357689. View

10.

Dunning M, Smith M, Ritchie M, Tavare S . beadarray: R classes and methods for Illumina bead-based data. Bioinformatics. 2007; 23(16):2183-4. DOI: 10.1093/bioinformatics/btm311. View

11.

Adukwu E, Bowles M, Edwards-Jones V, Bone H . Antimicrobial activity, cytotoxicity and chemical analysis of lemongrass essential oil (Cymbopogon flexuosus) and pure citral. Appl Microbiol Biotechnol. 2016; 100(22):9619-9627. PMC: 5071368. DOI: 10.1007/s00253-016-7807-y. View

12.

Tsai M, Lin C, Lin W, Yang C . Antimicrobial, antioxidant, and anti-inflammatory activities of essential oils from five selected herbs. Biosci Biotechnol Biochem. 2011; 75(10):1977-83. DOI: 10.1271/bbb.110377. View

13.

Barbosa-Morais N, Dunning M, Samarajiwa S, Darot J, Ritchie M, Lynch A . A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data. Nucleic Acids Res. 2009; 38(3):e17. PMC: 2817484. DOI: 10.1093/nar/gkp942. View

14.

Kandimalla R, Kalita S, Choudhury B, Dash S, Kalita K, Kotoky J . Chemical Composition and Anti-Candidiasis Mediated Wound Healing Property of Cymbopogon nardus Essential Oil on Chronic Diabetic Wounds. Front Pharmacol. 2016; 7:198. PMC: 4928018. DOI: 10.3389/fphar.2016.00198. View

15.

Han X, Rodriguez D, Parker T . Biological activities of frankincense essential oil in human dermal fibroblasts. Biochim Open. 2018; 4:31-35. PMC: 5801908. DOI: 10.1016/j.biopen.2017.01.003. View

16.

Yang S, Hua K, Lin Y, Chen A, Chang J, Chao L . Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice. PLoS One. 2013; 8(9):e74871. PMC: 3775727. DOI: 10.1371/journal.pone.0074871. View

17.

Bolstad B, Irizarry R, Astrand M, Speed T . A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003; 19(2):185-93. DOI: 10.1093/bioinformatics/19.2.185. View