I-J-positive Cloned Macrophages As Accessory Cells for the Induction of Suppressor T Cells in Vitro

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 1986 Jan 1

PMID 2944974

Citations 2

Authors

R M Nakamura

Y Nakamura

A Nagayama

T Tokunaga

Affiliations

Soon will be listed here.

Abstract

I-A+/I-J+ cloned macrophages, SL-1, played the role of APC in the in vitro induction of Ts against DTH to BCG. By treating SL-1 cells with various antibodies, it was shown that I-J antigens on SL-1 cells are essential for Ts induction, but not for the effector cell induction for DTH. Ia-negative cloned macrophages, SL-4, did not show any APC activity either in suppressor or effector cell induction. The precursors of the Ts were also I-J-positive, and I-J restriction resided between T cells and macrophages in the Ts induction. Thus, it is suggested that the pre-Ts recognizes the antigenic determinants of BCG presented on the APC in association with the I-J antigen and differentiates into the Ts. This pathway seems analogous to that of helper or effector T induction, where the antigenic determinant is recognized by a T cell in association with the I-A antigen on APC.

Citing Articles

Visualization of anti-I-J antibody binding sites on bone marrow-derived macrophages.

Nakamura R, Kitamura K Immunol Res. 1987; 6(3):210-4.

PMID: 3119745 DOI: 10.1007/BF02918092.

Cell-cell interaction responsible for the induction of first order suppressor T cells in hapten-specific contact sensitivity reactions.

Nakamura Y, Nakamura R, Tokunaga T Immunol Res. 1986; 5(2):117-28.

PMID: 2428888 DOI: 10.1007/BF02917586.

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