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Effects of Maturation and Advanced Glycation on Tensile Mechanics of Collagen Fibrils from Rat Tail and Achilles Tendons

Overview
Journal Acta Biomater
Publisher Elsevier
Date 2018 Feb 16
PMID 29447959
Citations 38
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Abstract

Statement Of Significance: Tendons are connective tissues that connect muscle to bone and carry some of the greatest mechanical loads in the body, which makes them common sites of injury. A tendon is essentially a biological rope formed by thin strands called fibrils made of the protein collagen. Tendon function relies on the strength of these fibrils, which in turn depends on naturally occurring cross-links between collagen molecules, but the mechanical influence of these cross-links have not been measured before. It is believed that beneficial cross-linking occurs with maturation while additional cross-linking with aging may lead to brittleness, but this study provides evidence that maturation has little effect on mechanical function and that age-related cross-linking does not result in brittle collagen fibrils.

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