Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 2018 Feb 16

PMID 29444955

Citations 8

Authors

Patrick A Gibney

Ariel Schieler

Jonathan C Chen

Jessie M Bacha-Hummel

Maxim Botstein

Matthew Volpe

Sanford J Silverman

Yifan Xu

Bryson D Bennett

Joshua D Rabinowitz

David Botstein

Affiliations

Soon will be listed here.

Abstract

Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.

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