Protective Effect of Uncaria Tomentosa Extract Against Oxidative Stress and Genotoxicity Induced by Glyphosate-Roundup® Using Zebrafish (Danio Rerio) As a Model

Overview

Journal Environ Sci Pollut Res Int

Publisher Springer

Specialties Environmental Health
Toxicology

Date 2018 Feb 15

PMID 29442306

Citations 11

Authors

Glaucia Dal Santo

Alan Grotto

Aline A Boligon

Barbara da Costa

Cassiano L Rambo

Emily A Fantini

Elisa Sauer

Luan M V Lazzarotto

Kanandra T Bertoncello

Osmar Tomazelli Junior

Solange C Garcia

Anna M Siebel

Denis B Rosemberg

Jacir Dal Magro

Greicy M M Conterato

Leila Zanatta

Affiliations

Soon will be listed here.

Abstract

Oxidative stress and DNA damage are involved in the glyphosate-based herbicide toxicity. Uncaria tomentosa (UT; Rubiaceae) is a plant species from South America containing bioactive compounds with known beneficial properties. The objective of this work was to evaluate the antioxidant and antigenotoxic potential of UT extract in a model of acute exposure to glyphosate-Roundup® (GR) in zebrafish (Danio rerio). We showed that UT (1.0 mg/mL) prevented the decrease of brain total thiols, the increase of lipid peroxidation in both brain and liver, and the decrease of liver GPx activity caused after 96 h of GR (5.0 mg/L) exposure. In addition, UT partially protected against the increase of micronucleus frequency induced by GR exposure in fish brain. Overall, our results indicate that UT protects against damage induced by a glyphosate-based herbicide by providing antioxidant and antigenotoxic effects, which may be related to the phenolic compounds identified in the extract.

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