IgD-binding Factors from Mouse T Lymphocytes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1986 Sep 1

PMID 2944119

Citations 8

Authors

M Adachi

K Ishizaka

Affiliations

Soon will be listed here.

Abstract

Incubation of normal mouse splenic lymphocytes with dimeric mouse IgD results in the formation of T-cell factors that selectively inhibit rosette formation of Fc delta receptor-positive lymphocytes with IgD-coated erythrocytes. The rosette-inhibiting factors bound to IgD-Sepharose and were recovered by elution at acid pH. The results indicate that the rosette-inhibiting factors are IgD-binding factors. Neither IgE-binding factors nor IgG-binding factors inhibited IgD rosettes. The IgD-binding factors induced by IgD consist of two species of molecular weight 78,000 and 37,000, respectively. The source of IgD-binding factors is Lyt-1+ T cells bearing Fc delta receptors. It appears that the binding of IgD to the receptors on the T cells induces the formation of IgD-binding factors.

Citing Articles

Molecular characterization of immunoglobulin D in mammals: immunoglobulin heavy constant delta genes in dogs, chimpanzees and four old world monkey species.

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Enhancement of antibody responses by IgD-binding factors induced by anti-IgD treatment of spleen cells.

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IgD antibodies to DNP are specifically induced in ascitic fluid after intraperitoneal immunization.

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Release of IgD-binding factor by T cells under the influence of interleukin 2, interleukin 4, or cross-linked IgD.

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Regulation of IgE synthesis. Lymphocyte Fc epsilon receptor, IgE binding factor(s), and glycosylation-modulating factors.

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