Role of Intestinal Flora in Colorectal Cancer from the Metabolite Perspective: a Systematic Review

Overview

Journal Cancer Manag Res

Publisher Dove Medical Press

Specialty Oncology

Date 2018 Feb 15

PMID 29440929

Citations 25

Authors

Shuwen Han

Jianlan Gao

Qing Zhou

Shanshan Liu

Caixia Wen

Xi Yang

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer is one of the most common human malignant tumors. Recent research has shown that colorectal cancer is a dysbacteriosis-induced disease; however, the role of intestinal bacteria in colorectal cancer is unclear. This review explores the role of intestinal flora in colorectal cancer. In total, 57 articles were included after identification and screening. The pertinent literature on floral metabolites in colorectal cancer from three metabolic perspectives - including carbohydrate, lipid, and amino acid metabolism - was analyzed. An association network regarding the role of intestinal flora from a metabolic perspective was constructed by analyzing the previous literature to provide direction and insight for further research on intestinal flora in colorectal cancer.

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