Zinc and Skin Disorders

Overview

Journal Nutrients

Date 2018 Feb 15

PMID 29439479

Citations 67

Authors

Youichi Ogawa

Manao Kinoshita

Shinji Shimada

Tatsuyoshi Kawamura

Affiliations

Soon will be listed here.

Abstract

The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Several human disorders accompanied with skin manifestations are caused by mutations or dysregulation in Zn transporters; acrodermatitis enteropathica (Zrt-, Irt-like protein (ZIP)4 in the intestinal epithelium and possibly epidermal basal keratinocytes), the spondylocheiro dysplastic form of Ehlers-Danlos syndrome (ZIP13 in the dermal fibroblasts), transient neonatal Zn deficiency (Zn transporter (ZnT)2 in the secretory vesicles of mammary glands), and epidermodysplasia verruciformis (ZnT1 in the epidermal keratinocytes). Additionally, acquired Zn deficiency is deeply involved in the development of some diseases related to nutritional deficiencies (acquired acrodermatitis enteropathica, necrolytic migratory erythema, pellagra, and biotin deficiency), alopecia, and delayed wound healing. Therefore, it is important to associate the existence of mutations or dysregulation in Zn transporters and Zn deficiency with skin manifestations.

Citing Articles

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Nutritional Dermatology: Optimizing Dietary Choices for Skin Health.

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The Nutrient-Skin Connection: Diagnosing Eating Disorders Through Dermatologic Signs.

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The Efficacy of Zinc Gluconate Supplementation in the Improvement of Malnutrition Indices and Skin Abnormalities in Hemodialysis Patients: A Randomized Clinical Trial.

Tavassoli M, Shahidi S, Askari G, Tavakoli N, Clark C, Rouhani M Int J Prev Med. 2025; 15:63.

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Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments.

Li H, Cui Y, Hu Y, Zhao M, Li K, Pang X Nat Commun. 2024; 15(1):10838.

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