A Comparison of the Haemodynamic Effects of Nifedipine, Nisoldipine and Nitrendipine in Man

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1986 Jan 1

PMID 2943594

Citations 6

Authors

N M Debbas

S H Jackson

P Turner

Affiliations

Soon will be listed here.

Abstract

Nifedipine (10 mg), nisoldipine (10 mg) and nitrendipine (20 mg) were given orally to 8 normal volunteers in a placebo controlled, double blind, crossover study. Blood pressure (BP), pulse (P) and systolic time intervals (STI) were recorded at time 0, 30, 60, 90, 120 min after drug administration. Adverse effects were also recorded. There was a fall in BP, pre-ejection time (PEP), PEP/LVET (left ventricular ejection time) and electro-mechanical systole index (QS2 index), and a rise in LVET index in response to the three active drugs compared with placebo. All active drugs, but not placebo, were associated with adverse effects.

Citing Articles

Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.

Goa K, Sorkin E Drugs. 1987; 33(2):123-55.

PMID: 3552592 DOI: 10.2165/00003495-198733020-00003.

Nisoldipine: kinetics and effects on blood pressure and heart rate in patients with liver cirrhosis after intravenous and oral administration.

van Harten J, van Brummelen P, Wilson J, Lodewijks M, Breimer D Eur J Clin Pharmacol. 1988; 34(4):387-94.

PMID: 3402524 DOI: 10.1007/BF00542441.

Acute inotropic effects of intravenous nifedipine and its vehicle compared with saline: a double-blind study of systolic time intervals in normal subjects.

Walley T, Heagerty A, Woods K, Bing R, Pohl J, Barnett D Br J Clin Pharmacol. 1988; 25(2):187-93.

PMID: 3358882 PMC: 1386473. DOI: 10.1111/j.1365-2125.1988.tb03290.x.

Nisoldipine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of angina pectoris, hypertension and related cardiovascular disorders.

Friedel H, Sorkin E Drugs. 1988; 36(6):682-731.

PMID: 3065058 DOI: 10.2165/00003495-198836060-00003.

Behavioral performance effects of nifedipine in normotensive and renovascular hypertensive baboons.

Turkkan J, Hienz R Psychopharmacology (Berl). 1990; 100(1):124-9.

PMID: 2296620 DOI: 10.1007/BF02245802.

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