Exon 3 Mutations of Drive Tumorigenesis: a Review

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 Feb 14

PMID 29435196

Citations 100

Authors

Chao Gao

Yingmei Wang

Russell Broaddus

Longhao Sun

Fengxia Xue

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

The canonical Wnt/β-catenin signaling pathway, an important modulator of progenitor cell proliferation and differentiation, is highly regulated for the maintenance of critical biological homeostasis. Decades of studies in cancer genetics and genomics have demonstrated that multiple genes encoding key proteins in this signaling pathway serve as targets for recurrent mutational alterations. Among these proteins, β-catenin and adenomatosis polyposis coli (APC) are two key nodes. β-catenin contributes in transporting extracellular signals for nuclear programming. Mutations of the gene that encodes β-catenin occur in a wide spectrum of cancers. These mutations alter the spatial characteristics of the β-catenin protein, leading to drastic reprogramming of the nuclear transcriptional network. Among the outcomes of this reprogramming are increased cell proliferation, enhanced immunosuppression, and disruption of metabolic regulation. Herein we review the current understanding of mutations, their roles in tumorigenesis and discuss their possible therapeutic implications for cancer.

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