Vaccination Against Lawsonia Intracellularis Decreases Shedding of Salmonella Enterica Serovar Typhimurium in Co-Infected Pigs and Alters the Gut Microbiome

Overview

Journal Sci Rep

Specialty Science

Date 2018 Feb 14

PMID 29434295

Citations 19

Authors

Fernando L L Leite

Randall S Singer

Tonya Ward

Connie J Gebhart

Richard E Isaacson

Affiliations

Soon will be listed here.

Abstract

Salmonella enterica serovar Typhimurium continues to be a major cause of foodborne illness worldwide and pork can serve as a source of infection. Co-infection of S. enterica with Lawsonia intracellularis, a common intestinal pathogen of swine, has been found as risk factor for increased S. enterica shedding. The objective of this study was to investigate if vaccination against L. intracellularis could lead to decreased S. Typhimurium shedding. To test this hypothesis, pigs were challenged with either S. Typhimurium or S. Typhimurium and L. intracellularis, with and without L. intracellularis vaccination (n = 9 per group). A non-challenged group served as a negative control. Vaccination decreased the shedding of S. Typhimurium in co-infected animals by 2.12 log organisms per gram of feces at 7 days post infection. Analysis of the microbiome showed that vaccination led to changes in the abundance of Clostridium species, including Clostridium butyricum, in addition to other compositional changes that may explain the protection mediated against S. Typhimurium. These results indicate that vaccination against L. intracellularis in co-infected herds may provide a new tool to increase food safety by helping to prevent S. enterica without the need for antibiotics.

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