Circular RNAs: a New Frontier for Cancer Diagnosis and Therapy

Overview

Journal J Hematol Oncol

Publisher Biomed Central

Specialties Hematology
Oncology

Date 2018 Feb 14

PMID 29433541

Citations 116

Authors

Miaoci Zhang

Yan Xin

Affiliations

Soon will be listed here.

Abstract

In recent years, circular RNAs (circRNAs) have attracted considerable attention because they play a significant role in many fields of cancer biology. Additionally, it has become increasingly clear that circRNAs have the potential to make contributions to the successful application of individualized cancer medicine. This brief review introduces circRNAs by describing their potential as a biomarker and therapeutic target and discussing the possible strategies to target them. This review also presents the challenges that are encountered by circRNAs for their definitive entry into clinical practice. Clearly, our understanding of circRNAs helps to add a new dimension to the molecular structure of cancer and will provide many new opportunities for cancer treatment.

Citing Articles

Construction and clinical application of a risk model based on N6-methyladenosine regulators for colorectal cancer.

Zhu H, Yang Y, Zhou Z PeerJ. 2024; 12:e18719.

PMID: 39717046 PMC: 11665428. DOI: 10.7717/peerj.18719.

Salivary biomarkers: a promising approach for predicting immunotherapy response in head and neck cancers.

Nejat Dehkordi A, Maddahi M, Vafa P, Ebrahimi N, Aref A Clin Transl Oncol. 2024; .

PMID: 39377974 DOI: 10.1007/s12094-024-03742-8.

Role of circular RNAs in preeclampsia (Review).

Jiang H, Meng T, Li Z Exp Ther Med. 2024; 28(4):372.

PMID: 39091629 PMC: 11292168. DOI: 10.3892/etm.2024.12661.

Ramifications of m6A Modification on ncRNAs in Cancer.

Mehmood R Curr Genomics. 2024; 25(3):158-170.

PMID: 39087001 PMC: 11288162. DOI: 10.2174/0113892029296712240405053201.

Readers of RNA Modification in Cancer and Their Anticancer Inhibitors.

Li F, Li W Biomolecules. 2024; 14(7).

PMID: 39062595 PMC: 11275166. DOI: 10.3390/biom14070881.

References

Chen X, Fan S, Song E . Noncoding RNAs: New Players in Cancers. Adv Exp Med Biol. 2016; 927:1-47. DOI: 10.1007/978-981-10-1498-7_1. View

Tian Y, Li S, Song J, Ji T, Zhu M, Anderson G . A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials. 2013; 35(7):2383-90. DOI: 10.1016/j.biomaterials.2013.11.083. View

Li J, Zhen L, Zhang Y, Zhao L, Liu H, Cai D . Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. Onco Targets Ther. 2017; 10:3521-3529. PMC: 5522828. DOI: 10.2147/OTT.S136347. View

Guarnerio J, Bezzi M, Jeong J, Paffenholz S, Berry K, Naldini M . Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Cell. 2016; 166(4):1055-1056. DOI: 10.1016/j.cell.2016.07.035. View

Xuan L, Qu L, Zhou H, Wang P, Yu H, Wu T . Circular RNA: a novel biomarker for progressive laryngeal cancer. Am J Transl Res. 2016; 8(2):932-9. PMC: 4846937. View

Jeck W, Sharpless N . Detecting and characterizing circular RNAs. Nat Biotechnol. 2014; 32(5):453-61. PMC: 4121655. DOI: 10.1038/nbt.2890. View

Zhang Y, Zhang X, Chen T, Xiang J, Yin Q, Xing Y . Circular intronic long noncoding RNAs. Mol Cell. 2013; 51(6):792-806. DOI: 10.1016/j.molcel.2013.08.017. View

Zhong Z, Huang M, Lv M, He Y, Duan C, Zhang L . Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway. Cancer Lett. 2017; 403:305-317. DOI: 10.1016/j.canlet.2017.06.027. View

Wan L, Zhang L, Fan K, Cheng Z, Sun Q, Wang J . Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway. Biomed Res Int. 2016; 2016:1579490. PMC: 5013215. DOI: 10.1155/2016/1579490. View

10.

Zhu L, He Y, Hou J, Chen X, Zhou S, Yang S . The role of circRNAs in cancers. Biosci Rep. 2017; 37(5). PMC: 5653918. DOI: 10.1042/BSR20170750. View

11.

Fu L, Wu S, Yao T, Chen Q, Xie Y, Ying S . Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance. J Clin Lab Anal. 2017; 32(2). PMC: 6816847. DOI: 10.1002/jcla.22239. View

12.

Liu J, Liu T, Wang X, He A . Circles reshaping the RNA world: from waste to treasure. Mol Cancer. 2017; 16(1):58. PMC: 5345220. DOI: 10.1186/s12943-017-0630-y. View

13.

Chen J, Li Y, Zheng Q, Bao C, He J, Chen B . Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Lett. 2016; 388:208-219. DOI: 10.1016/j.canlet.2016.12.006. View

14.

Ren S, Xin Z, Xu Y, Xu J, Wang G . Construction and analysis of circular RNA molecular regulatory networks in liver cancer. Cell Cycle. 2017; 16(22):2204-2211. PMC: 5736333. DOI: 10.1080/15384101.2017.1346754. View

15.

Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J . Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015; 25(8):981-4. PMC: 4528056. DOI: 10.1038/cr.2015.82. View

16.

Xiong W, Ai Y, Li Y, Ye Q, Chen Z, Qin J . Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Biomed Res Int. 2017; 2017:8421614. PMC: 5471554. DOI: 10.1155/2017/8421614. View

17.

Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B . Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 2016; 7:11215. PMC: 4823868. DOI: 10.1038/ncomms11215. View

18.

Liang H, Zhang X, Liu B, Jia G, Li W . Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Am J Cancer Res. 2017; 7(7):1566-1576. PMC: 5523036. View

19.

Zirkel A, Papantonis A . Detecting Circular RNAs by RNA Fluorescence In Situ Hybridization. Methods Mol Biol. 2018; 1724:69-75. DOI: 10.1007/978-1-4939-7562-4_6. View

20.

Shang X, Li G, Liu H, Li T, Liu J, Zhao Q . Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development. Medicine (Baltimore). 2016; 95(22):e3811. PMC: 4900729. DOI: 10.1097/MD.0000000000003811. View