Characterization of Japanese éncephalitis Virus-induced Suppressor T Cells and Their Products for Delayed Type Hypersensitivity

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1986 Aug 1

PMID 2943310

Citations 1

Authors

S Rawat

A Mathur

U C Chaturvedi

Affiliations

Soon will be listed here.

Abstract

Intraperitoneal inoculation with Japanese encephalitis virus (JEV) induces the generation of T suppressor cells for delayed type hypersensitivity (Ts-DTH) in Swiss albino mice. The Ts-DTH are hydrocortisone resistant, partially sensitive to X-irradiation and the membrane phenotype of Ts cells is Ly I+. Ts-DTH suppression is mediated through the production of soluble suppressor factor (SF-DTH). SF-DTH is non-dialysable but passes through 450 nm filter and does not sediment after centrifugation at 100,000 g for 2 h; chromatography on Sephadex G-100 indicates an approximate molecular weight of 12,000.

Citing Articles

Memory suppressor T cells in latent Japanese encephalitis virus infection.

Mathur A, Kulshreshtha R, Rawat S, Chaturvedi U Immunology. 1987; 60(1):71-4.

PMID: 2434414 PMC: 1453365.

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