Investigation of Function and Regulation of the YB-1 Cellular Factor in HIV Replication

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2018 Feb 13

PMID 29429449

Citations 5

Authors

Yu-Mi Jung

Kyung-Lee Yu

Seong-Hyun Park

Seong-Deok Lee

Min-Jeong Kim

Ji-Chang You

Affiliations

Soon will be listed here.

Abstract

Y-box binding protein 1 (YB-1) is a member of the cold-shock domain (CSD) protein superfamily. It participates in a wide variety of cellular events, including transcription, RNA splicing, translation, DNA repair, drug resistance, and stress responses. We investigated putative functions of YB-1 in HIV-1 replication. Functional studies using overexpression or knockdown of YB-1 in conjunction with transfection of proviral DNA showed that YB-1 enhances virus production. We found YB-1 regulates HIV-1 production by stimulating viral transcription using HIV-1 LTR sequence U3RU5 with Luciferase assay. We also identified a specific region from amino acids 1 to 324 of YB-1 as necessary for the participation of the protein in the production of virions. [BMB Reports 2018; 51(6): 290-295].

Citing Articles

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