Central Effect of Atrial Natriuretic Polypeptide on Angiotensin II-stimulated Vasopressin Secretion in Conscious Rats

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1986 Jun 24

PMID 2942414

Citations 9

Authors

T Yamada

K Nakao

N MORII

H Itoh

S Shiono

M Sakamoto

A Sugawara

Y Saito

H Ohno

A Kanai

Affiliations

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Abstract

The effect of intracerebroventricular (i.c.v.) treatment of alpha-human atrial natriuretic polypeptide on the vasopressin secretion induced by i.c.v. injection of angiotensin II was studied in conscious, unrestrained rats. Pretreatment of alpha-human atrial natriuretic polypeptide (5 micrograms) significantly inhibited the angiotensin II (100 ng)-stimulated vasopressin secretion. This result suggests that atrial natriuretic polypeptide plays regulatory roles in vasopressin secretion in the central nervous system.

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