Direct Palladium-Catalyzed β-Arylation of Lactams

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2018 Feb 10

PMID 29424015

Citations 6

Authors

Ming Chen

Feipeng Liu

Guangbin Dong

Affiliations

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Abstract

A direct and catalytic method is reported here for β-arylation of N-protected lactams with simple aryl iodides. The transformation is enabled by merging soft enolization of lactams, palladium-catalyzed desaturation, Ar-X bond activation, and aryl conjugate addition. The reaction is operated under mild reaction conditions, is scalable, and is chemoselective. Application of this method to concise syntheses of pharmaceutically relevant compounds is demonstrated.

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