Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2018 Feb 10

PMID 29423819

Citations 12

Authors

Jalaluddin M Ashraf

Mohammad Azam Ansari

Sana Fatma

Saleh M S Abdullah

Johar Iqbal

Aymen Madkhali

Al Hassan Hamali

Saheem Ahmad

Ahmed Jerah

Valentina Echeverria

George E Barreto

Ghulam Md Ashraf

Affiliations

Soon will be listed here.

Abstract

Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson's diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications.

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