Effect of Water and Ionic Liquids on Biomolecules

Overview

Journal Biophys Rev

Publisher Springer

Specialty Biophysics

Date 2018 Feb 10

PMID 29423700

Citations 9

Authors

Debasis Saha

Arnab Mukherjee

Affiliations

Soon will be listed here.

Abstract

The remarkable progress in the field of ionic liquids (ILs) in the last two decades has involved investigations on different aspects of ILs in various conditions. The nontoxic and biocompatible nature of ILs makes them a suitable substance for the storage and application of biomolecules. In this regard, the aqueous IL solutions have attracted a large number of studies to comprehend the role of water in modulating various properties of biomolecules. Here, we review some of the recent studies on aqueous ILs that concern the role of water in altering the behavior of ILs in general and in case of biomolecules solvated in ILs. The different structural and dynamic effects caused by water have been highlighted. We discuss the different modes of IL interaction that are responsible for stabilization and destabilization of proteins and enzymes followed by examples of water effect on this. The role of water in the case of nucleic acid storage in ILs, an area which has mostly been underrated, also has been emphasized. Our discussions highlight the fact that the effects of water on IL behavior are not general and are highly dependent on the nature of the IL under consideration. Overall, we aim to draw attention to the significance of water dynamics in the aqueous IL solutions, a better understanding of which can help in developing superior storage materials for application purposes.

Citing Articles

Fluctuations in Medium Viscosity May Affect the Stability of the CAG Tract in the Gene.

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Insights into Ionic Liquids: From Z-Bonds to Quasi-Liquids.

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Influence of Environmental Parameters on the Stability of the DNA Molecule.

Svidlov A, Drobotenko M, Basov A, Gerasimenko E, Elkina A, Baryshev M Entropy (Basel). 2021; 23(11).

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Use of Ionic Liquids in Protein and DNA Chemistry.

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PMID: 33425856 PMC: 7786294. DOI: 10.3389/fchem.2020.598662.

Synergistic interactions of ionic liquids and antimicrobials improve drug efficacy.

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