The Material and Biological Characteristics of Osteoinductive Calcium Phosphate Ceramics

Overview

Journal Regen Biomater

Specialty Biomedical Engineering

Date 2018 Feb 10

PMID 29423267

Citations 79

Authors

Zhurong Tang

Xiangfeng Li

Yanfei Tan

Hongsong Fan

Xingdong Zhang

Affiliations

Soon will be listed here.

Abstract

The discovery of osteoinductivity of calcium phosphate (Ca-P) ceramics has set an enduring paradigm of conferring biological regenerative activity to materials with carefully designed structural characteristics. The unique phase composition and porous structural features of osteoinductive Ca-P ceramics allow it to interact with signaling molecules and extracellular matrices in the host system, creating a local environment conducive to new bone formation. Mounting evidence now indicate that the osteoinductive activity of Ca-P ceramics is linked to their physicochemical and three-dimensional structural properties. Inspired by this conceptual breakthrough, many laboratories have shown that other materials can be also enticed to join the rank of tissue-inducing biomaterials, and besides the bones, other tissues such as cartilage, nerves and blood vessels were also regenerated with the assistance of biomaterials. Here, we give a brief historical recount about the discovery of the osteoinductivity of Ca-P ceramics, summarize the underlying material factors and biological characteristics, and discuss the mechanism of osteoinduction concerning protein adsorption, and the interaction with different types of cells, and the involvement of the vascular and immune systems.

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References

Barradas A, Monticone V, Hulsman M, Danoux C, Fernandes H, Tahmasebi Birgani Z . Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells. Integr Biol (Camb). 2013; 5(7):920-31. DOI: 10.1039/c3ib40027a. View

Urist M . Bone: formation by autoinduction. Science. 1965; 150(3698):893-9. DOI: 10.1126/science.150.3698.893. View

Betsholtz C, Lindblom P, Gerhardt H . Role of pericytes in vascular morphogenesis. EXS. 2004; (94):115-25. DOI: 10.1007/3-7643-7311-3_8. View

Chai Y, Roberts S, Schrooten J, Luyten F . Probing the osteoinductive effect of calcium phosphate by using an in vitro biomimetic model. Tissue Eng Part A. 2010; 17(7-8):1083-97. DOI: 10.1089/ten.TEA.2010.0160. View

Yuan H, Zou P, Yang Z, Zhang X, de Bruijn J, de Groot K . Bone morphogenetic protein and ceramic-induced osteogenesis. J Mater Sci Mater Med. 2004; 9(12):717-21. DOI: 10.1023/a:1008998817977. View

Winter G, Simpson B . Heterotopic bone formed in a synthetic sponge in the skin of young pigs. Nature. 1969; 223(5201):88-90. DOI: 10.1038/223088a0. View

Kovacic J, Boehm M . Resident vascular progenitor cells: an emerging role for non-terminally differentiated vessel-resident cells in vascular biology. Stem Cell Res. 2009; 2(1):2-15. PMC: 2630171. DOI: 10.1016/j.scr.2008.05.005. View

Yamasaki H, Sakai H . Osteogenic response to porous hydroxyapatite ceramics under the skin of dogs. Biomaterials. 1992; 13(5):308-12. DOI: 10.1016/0142-9612(92)90054-r. View

Zhang L, Hanagata N, Maeda M, Minowa T, Ikoma T, Fan H . Porous hydroxyapatite and biphasic calcium phosphate ceramics promote ectopic osteoblast differentiation from mesenchymal stem cells. Sci Technol Adv Mater. 2016; 10(2):025003. PMC: 5090447. DOI: 10.1088/1468-6996/10/2/025003. View

10.

Chen Z, Wu C, Gu W, Klein T, Crawford R, Xiao Y . Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials. 2013; 35(5):1507-18. DOI: 10.1016/j.biomaterials.2013.11.014. View

11.

Moonen J, Krenning G, Brinker M, Koerts J, van Luyn M, Harmsen M . Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny. Cardiovasc Res. 2010; 86(3):506-15. DOI: 10.1093/cvr/cvq012. View

12.

Sorescu G, Song H, Tressel S, Hwang J, Dikalov S, Smith D . Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Circ Res. 2004; 95(8):773-9. DOI: 10.1161/01.RES.0000145728.22878.45. View

13.

Tat S, Padrines M, Theoleyre S, Heymann D, Fortun Y . IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev. 2004; 15(1):49-60. DOI: 10.1016/j.cytogfr.2003.10.005. View

14.

Shi M, Zhou Y, Shao J, Chen Z, Song B, Chang J . Stimulation of osteogenesis and angiogenesis of hBMSCs by delivering Si ions and functional drug from mesoporous silica nanospheres. Acta Biomater. 2015; 21:178-89. DOI: 10.1016/j.actbio.2015.04.019. View

15.

Fellah B, Josselin N, Chappard D, Weiss P, Layrolle P . Inflammatory reaction in rats muscle after implantation of biphasic calcium phosphate micro particles. J Mater Sci Mater Med. 2007; 18(2):287-94. DOI: 10.1007/s10856-006-0691-8. View

16.

Lin L, Chow K, Leng Y . Study of hydroxyapatite osteoinductivity with an osteogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A. 2008; 89(2):326-35. DOI: 10.1002/jbm.a.31994. View

17.

Fujibayashi S, Neo M, Kim H, Kokubo T, Nakamura T . Osteoinduction of porous bioactive titanium metal. Biomaterials. 2003; 25(3):443-50. DOI: 10.1016/s0142-9612(03)00551-9. View

18.

Liu H, Xu G, Wang Y, Zhao H, Xiong S, Wu Y . Composite scaffolds of nano-hydroxyapatite and silk fibroin enhance mesenchymal stem cell-based bone regeneration via the interleukin 1 alpha autocrine/paracrine signaling loop. Biomaterials. 2015; 49:103-12. DOI: 10.1016/j.biomaterials.2015.01.017. View

19.

Rehman I, Hench L, Bonfield W, Smith R . Analysis of surface layers on bioactive glasses. Biomaterials. 1994; 15(10):865-70. DOI: 10.1016/0142-9612(94)90044-2. View

20.

Kanatani M, Sugimoto T, Fukase M, Fujita T . Effect of elevated extracellular calcium on the proliferation of osteoblastic MC3T3-E1 cells:its direct and indirect effects via monocytes. Biochem Biophys Res Commun. 1991; 181(3):1425-30. DOI: 10.1016/0006-291x(91)92098-5. View