Haplotype Association of the Gene with Antipsychotics-Induced Symptoms of Restless Legs Syndrome Among Patients with Schizophrenia

Overview

Journal Psychiatry Investig

Specialty Psychiatry

Date 2018 Feb 10

PMID 29422930

Citations 4

Authors

Seung-Gul Kang

Yu Jin Lee

Young-Min Park

Leen Kim

Heon-Jeong Lee

Affiliations

Soon will be listed here.

Abstract

Objective: Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of are associated with antipsychotics-induced RLS in schizophrenia.

Methods: We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. Five single-nucleotide polymorphisms (SNPs) of were genotyped. We investigated genetic and haplotypic associations of these five SNPs with the risk of antipsychotics-induced RLS symptoms.

Results: We divided the 190 subjects into 2 groups: 1) those with RLS symptoms (n=96) and 2) those without RLS symptoms (n=94). There were no significant intergroup differences in the distributions of the genotypes and alleles of the rs1026732, rs11635424, rs12593813, rs4489954, and rs3784709 SNPs. However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033).

Conclusion: These data suggest that a haplotype of polymorphisms confers increased susceptibility to antipsychotics-induced RLS symptoms in schizophrenic patients.

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