An Update on Oxysterol Biochemistry: New Discoveries in Lipidomics

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2018 Feb 9

PMID 29421651

Citations 16

Authors

William J Griffiths

Yuqin Wang

Affiliations

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Abstract

Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries.

Citing Articles

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Effects of Oxysterols on Immune Cells and Related Diseases.

de Freitas F, Levy D, Reichert C, Cunha-Neto E, Kalil J, Bydlowski S Cells. 2022; 11(8).

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