The Change in the Percent of Android and Gynoid Fat Mass Correlated with Increased Testosterone After Laparoscopic Sleeve Gastrectomy in Chinese Obese Men: a 6-Month Follow-Up

Overview

Journal Obes Surg

Date 2018 Feb 9

PMID 29417486

Citations 9

Authors

Jingyang Gao

Manna Zhang

Cuiling Zhu

Yi Zhang

Qi Liu

Xingchun Wang

Liang Li

Donglei Zhou

Shen Qu

Affiliations

Soon will be listed here.

Abstract

Objective: The study was designed to examine changes of body fat distribution after laparoscopic sleeve gastrectomy (LSG) in obese male patients and to confirm whether these changes are correlated with increased testosterone.

Methods: A total of 30 obese male patients with body mass index (BMI) 30-45 kg/m were enrolled in this study. Data on demographic characteristics, anthropometry, metabolic parameters, and body fat distribution were collected at baseline and 6 months after LSG. Body fat distribution was assessed by dual-energy X-ray absorptiometry (DXA).

Results: Six months after surgery, the BMI of participants (age 33.0 ± 9.5) decreased from 40.2 ± 5.2 to 30.8 ± 4.4 kg/m, total testosterone increased from 2.4 ± 1.2 to 4.5 ± 1.8 ng/mL, and the percentage of testosterone deficiency in these patients decreased from 82.7 to 23.1%. Fat mass was significantly decreased in all regions, but the loss of fat mass in the android region was more than that in any other body region. After adjusting age and the BMI, the changes in android FM% and gynoid FM% were significantly correlated with an increase in total testosterone concentration (R = 0.187, R = 0.282, respectively).

Conclusion: In obese male patients with BMI 30-45 kg/m, an increase of total testosterone correlated to the changes in android FM% and gynoid FM% at the sixth month after LSG surgery.

Citing Articles

Association of Sex Hormones and Fat Distribution in Men with Different Obese and Metabolic Statuses.

Zhou Y, Guo Y, Wang F, Zhou C, Tang C, Tang H Int J Gen Med. 2022; 15:1225-1238.

PMID: 35173463 PMC: 8841523. DOI: 10.2147/IJGM.S351282.

Lower Baseline Serum Triglyceride Levels Are Associated With Higher Decrease in Body Mass Index After Laparoscopy Sleeve Gastrectomy Among Obese Patients.

Huang X, Li G, Xu B, Zhang J, Wang X, Cheng X Front Endocrinol (Lausanne). 2021; 12:633856.

PMID: 33692759 PMC: 7937917. DOI: 10.3389/fendo.2021.633856.

Peculiar Skin Rash After Laparoscopic Sleeve Gastrectomy.

Eghleilib M, Eghlileb A, Al-Alem I, Sriwi D, Elshaer A Am J Case Rep. 2020; 21:e920728.

PMID: 32669532 PMC: 7377524. DOI: 10.12659/AJCR.920728.

Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity.

Chen S, Yuan K, Lee Y, Shih C, Tseng S, Tinkov A Antioxidants (Basel). 2020; 9(3).

PMID: 32235809 PMC: 7139764. DOI: 10.3390/antiox9030261.

Legend of Weight Loss: a Crosstalk Between the Bariatric Surgery and the Brain.

Lin Z, Qu S Obes Surg. 2020; 30(5):1988-2002.

PMID: 32096018 DOI: 10.1007/s11695-020-04474-8.

References

OReilly M, House P, Tomlinson J . Understanding androgen action in adipose tissue. J Steroid Biochem Mol Biol. 2014; 143:277-84. DOI: 10.1016/j.jsbmb.2014.04.008. View

Foulkes S, Daly R, Fraser S . The clinical importance of quantifying body fat distribution during androgen deprivation therapy for prostate cancer. Endocr Relat Cancer. 2017; 24(3):R35-R48. DOI: 10.1530/ERC-16-0505. View

Corona G, Rastrelli G, Monami M, Saad F, Luconi M, Lucchese M . Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. Eur J Endocrinol. 2013; 168(6):829-43. DOI: 10.1530/EJE-12-0955. View

Calderon B, Galdon A, Calanas A, Peromingo R, Galindo J, Garcia-Moreno F . Effects of bariatric surgery on male obesity-associated secondary hypogonadism: comparison of laparoscopic gastric bypass with restrictive procedures. Obes Surg. 2014; 24(10):1686-92. DOI: 10.1007/s11695-014-1233-y. View

Li W, Zhu L, Mo Z, Yang X, Wang G, Li P . Effect of laparoscopic Roux-en-Y gastric bypass on body composition and insulin resistance in Chinese patients with type 2 diabetes mellitus. Obes Surg. 2013; 24(4):578-83. DOI: 10.1007/s11695-013-1116-7. View

Tajar A, Forti G, ONeill T, Lee D, Silman A, Finn J . Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. J Clin Endocrinol Metab. 2010; 95(4):1810-8. DOI: 10.1210/jc.2009-1796. View

Frederiksen L, Hojlund K, Hougaard D, Mosbech T, Larsen R, Flyvbjerg A . Testosterone therapy decreases subcutaneous fat and adiponectin in aging men. Eur J Endocrinol. 2011; 166(3):469-76. DOI: 10.1530/EJE-11-0565. View

Laughlin G, Ix J, Cummins K, Allison M, Daniels L . Extremes of an aromatase index predict increased 25-year risk of cardiovascular mortality in older women. Clin Endocrinol (Oxf). 2011; 77(3):391-8. PMC: 3298636. DOI: 10.1111/j.1365-2265.2011.04287.x. View

Wittert G, Chapman I, Haren M, Mackintosh S, Coates P, Morley J . Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status. J Gerontol A Biol Sci Med Sci. 2003; 58(7):618-25. DOI: 10.1093/gerona/58.7.m618. View

10.

Kvist H, Chowdhury B, Grangard U, Tylen U, Sjostrom L . Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations. Am J Clin Nutr. 1988; 48(6):1351-61. DOI: 10.1093/ajcn/48.6.1351. View

11.

Li Y, Zhang M, Liu X, Cui W, Rampersad S, Li F . Correlates and prevalence of hypogonadism in patients with early- and late-onset type 2 diabetes. Andrology. 2017; 5(4):739-743. DOI: 10.1111/andr.12360. View

12.

Bhasin S, Cunningham G, Hayes F, Matsumoto A, Snyder P, Swerdloff R . Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010; 95(6):2536-59. DOI: 10.1210/jc.2009-2354. View

13.

Sartorius G, Ly L, Sikaris K, McLachlan R, Handelsman D . Predictive accuracy and sources of variability in calculated free testosterone estimates. Ann Clin Biochem. 2009; 46(Pt 2):137-43. DOI: 10.1258/acb.2008.008171. View

14.

Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U . Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest. 1983; 72(3):1150-62. PMC: 1129283. DOI: 10.1172/JCI111040. View

15.

Mouser J, Loprinzi P, Loenneke J . The association between physiologic testosterone levels, lean mass, and fat mass in a nationally representative sample of men in the United States. Steroids. 2016; 115:62-66. DOI: 10.1016/j.steroids.2016.08.009. View

16.

Ly L, Sartorius G, Hull L, Leung A, Swerdloff R, Wang C . Accuracy of calculated free testosterone formulae in men. Clin Endocrinol (Oxf). 2010; 73(3):382-8. DOI: 10.1111/j.1365-2265.2010.03804.x. View

17.

Mammi C, Calanchini M, Antelmi A, Cinti F, Rosano G, Lenzi A . Androgens and adipose tissue in males: a complex and reciprocal interplay. Int J Endocrinol. 2012; 2012:789653. PMC: 3253446. DOI: 10.1155/2012/789653. View

18.

Luconi M, Samavat J, Seghieri G, Iannuzzi G, Lucchese M, Rotella C . Determinants of testosterone recovery after bariatric surgery: is it only a matter of reduction of body mass index?. Fertil Steril. 2013; 99(7):1872-9.e1. DOI: 10.1016/j.fertnstert.2013.02.039. View

19.

Bann D, Wu F, Keevil B, Lashen H, Adams J, Hardy R . Changes in testosterone related to body composition in late midlife: Findings from the 1946 British birth cohort study. Obesity (Silver Spring). 2015; 23(7):1486-92. PMC: 4744737. DOI: 10.1002/oby.21092. View

20.

Cooper L, Page S, Amory J, Anawalt B, Matsumoto A . The association of obesity with sex hormone-binding globulin is stronger than the association with ageing--implications for the interpretation of total testosterone measurements. Clin Endocrinol (Oxf). 2015; 83(6):828-33. PMC: 4782930. DOI: 10.1111/cen.12768. View