[Metabolism of Monocarbons and Trisomy 21: Sensitivity to Methotrexate]

Overview

Journal Ann Genet

Publisher Elsevier

Specialty Genetics

Date 1986 Jan 1

PMID 2940958

Citations 8

Authors

J LeJeune

M O Rethore

M C de Blois

M Mir

L Nicolle

F Borowy

E Borghi

D Recan

Affiliations

Soon will be listed here.

Abstract

A diminution of the mitotic index, proportionnal to the square of the dose of methotrexate, was observed in lymphocyte cultures. Six trisomy 21 patients were twice as sensitive as six controls. This highly significant result confirms the hypothesis of a disturbance of monocarbons' metabolism in trisomy 21.

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The transcriptome profile of human trisomy 21 blood cells.

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