Medulloblastoma in Association with Sacral Agenesis; a Case Report

Overview

Journal Childs Nerv Syst

Specialty Pediatrics

Date 2018 Feb 7

PMID 29404676

Authors

Zahra Ebrahim Soltani

Zohreh Habibi

Farideh Nejat

Affiliations

Soon will be listed here.

Abstract

Medulloblastoma is a congenital brain tumor which can be associated with different congenital anomalies. However, coincidence of cerebellar medulloblastoma with sacral agenesis has not been reported so far. A variety of genetic and/or environmental predisposing factors have been proposed for both diseases. Herein, an unprecedented coincidence of these two conditions is presented. A neonate was born with lumbosacral agenesis, paraplegia, and atrophic legs, and he developed medulloblastoma with three ventricular hydrocephalus 3 years later. Different aspects regarding the embryology and etiology of both ailments are discussed, assuming the possibility that the same genetic and/or environmental risk factors may have played a part in both conditions.

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